Abstract
By the NMR method, the chemical shifts characterizing the methyl groups in monohydroxymonomethyl derivatives of pyrimidine have been determined. The changes in the chemical shifts and the activities of the methyl groups are symbatic. It has been shown by the NMR method that when 6-hydroxy-2,4-dimethylpyrimidine reacts with benzaldehyde and with p-nitrobenzenediazonium salts reactions take place through the methyl group in position 2. A gradual decrease in the activity of the methyl groups is found in the sequence of 6-hydroxy-, 6-mercapto-, and 6-aminoderivatives of 2,4-dimethylpyrimidine.
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For part XVII, see [5].
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Serzhanina, V.A., Khromov-Borisov, N.V. & Karlinskaya, R.S. Syntheses and reactions of pyrimidine derivatives. Chem Heterocycl Compd 4, 390–392 (1968). https://doi.org/10.1007/BF00755294
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DOI: https://doi.org/10.1007/BF00755294