Summary
A case of multifocal renal cell carcinoma (RCC) is reported. A detailed cytogenetic study revealed diverse clonal chromosomal aberrations in both tumours and demonstrated the multiple origin of these tumours. The tool of chromosome analysis in discriminating between multifocal renal cell tumours and local metastasis, as well as in the determination of renal adenomas and carcinomas is discussed.
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References
Bennington JL, Beckwith JB (1975) Tumors of the Kidney, Renal Pelvis, and Ureter, Fascicle 12. Atlas of Tumor Pathology, 2nd series, Armed Forces Institute of Pathology, Washington DC
Cohen AJ, Frederick P, Li P, Berg S, Marchetto DJ, Tsai S, Jacobs SC, Brown RS (1979) Hereditary renal-cell carcinoma associated with a chromosomal translocation. N Engl J Med 301:592–595
Fisher ER, Horva B (1972) Comparative ultrastructural study of so-called renal adenoma and carcinoma. J Urol 108:382–387
I.S.C.N. (1985) An International system for human cytogenetic nomenclature. Cytogenet Cell Genet
Kovacs G, Szücs S, DeRiese W, Baumgärtel H (1987) Specific chromosome aberration in human renal cell carcinoma. Int J Cancer 40:171–178
Mostofi FK (1981) Histological typing of kidney tumours. Int Histol Classification of Tumours, No. 25, World Health Organization, Geneva
Nowell PC (1976) The clonal evolution of tumour cell populations. Science 194:23–28
Pathak S, Strong LC, Ferrell RE, Trindade A (1982) Familial renal cell carcinoma with a 3;11 chromosome translocation limited to tumor cells. Science 217:939–941
Richards RD, Melust WK, Schrinke RN (1973) A prospective study of von Hippel-Lindau disease. J Urol 110:27–30
Schubert GE (1984) Niere und ableitende Harnwege. In: Remmele W (ed) Pathologie, vol. 3, Springer, Berlin Heidelberg New York, pp 95
Thoenes W, Störkel S, Rumpelt HJ (1986) Histopathology and classification of renal cell tumours (Adenomas, oncocytomas and carcinomas). The basic cytological and histopathological elements and their use for diagnostics. Pathol Res Pract 181:125–143
Vermillion CD, Skinner DG, Pfister RC (1972) Bilateral renal cell carcinoma. J Urol 108:219–222
Yoshida MA, Ohyashiki K, Ochi H, Gibas Z, Pontes E, Prout GR, Huben R, Sandberg AA (1986) Cytogenetic studies of tumor tissue from patients with nonfamilial renal cell carcinoma. Cancer Res 46:2139–2147
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Kovacs, G., Hoene, E. Multifocal renal cell carcinoma: A cytogenetic study. Vichows Archiv A Pathol Anat 412, 79–82 (1987). https://doi.org/10.1007/BF00750734
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DOI: https://doi.org/10.1007/BF00750734