Virchows Archiv A

, Volume 412, Issue 1, pp 31–36 | Cite as

Solitary mastocytoma of the eyelid

A case report with special reference to the immunocytology of human tissue mast cells, and a review of the literature
  • Olga Scheck
  • Hans-Peter Horny
  • Peter Ruck
  • Rainer Schmelzle
  • Edwin Kaiserling


Solitary mastocytoma (mast cell naevus) of the skin represents a relatively rare dermal tumour. Its occurrence on the lower eyelid is exceptional. We report the case of a 4 month old male infant who exhibited a firm, yellowish nodule (1 cm in maximum diameter) on the lower lid of the right eye from birth. Histologically, the tumour consisted of strongly metachromatic tissue mast cells (TMC) infiltrating the whole dermis, the adjacent subcutaneous tissue and the lid muscle. Since comparable skin lesions in other sites were not observed, a diagnosis of solitary mastocytoma was made. Immunocytological investigations revealed strong reactivity of the TMC to antisera against vimentin, common leucocyte antigen (CLA),α1-antitrypsin (α1-AT) and α1-antichymotrypsin (α1-ACT). A minor proportion of the TMC reacted to antisera against lysozyme and KiB3. Surprisingly, the TMC also reacted to antisera against certain regulatory peptides (RP), namely adrenocorticotropic hormone (ACTH), peptide histidine isoleucine (PHI), leu-enkephalin and met-enkephalin. However, absorption controls revealed that the immunostaining for ACTH and the two enkephalins was non-specific. The immunocytological phenotype of TMC suggests a close relationship to the myeloid-monocytic lineage, but a possible relationship between TMC and the diffuse neuroendocrine system needs further investigation.

Key words

Eyelid tumour Immunocytology Mastocytoma Tissue mast cell 


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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • Olga Scheck
    • 1
  • Hans-Peter Horny
    • 1
  • Peter Ruck
    • 1
  • Rainer Schmelzle
    • 2
  • Edwin Kaiserling
    • 1
  1. 1.Institute of PathologyEberhard-Karls-UniversityTübingenFederal Republic of Germany
  2. 2.Department of Faciomaxillary SurgeryEberhard-Karls-UniversityTübingenFederal Republic of Germany

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