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Electrophilic substitution in the benzene ring of indole compounds (Review)

Abstract

Data on the orientation of electrophilic substitution reactions (nitration, halogenation, acylation, and sulfonation) in the benzene ring of indoles are systematized. The effect of protonation on the direction of substitution is examined. The effects of a pyrrole ring and a substituent in the benzene ring on the orientation reactions are compared.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1181–1199, September, 1980.

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Budylin, V.A., Yudin, L.G. & Kost, A.N. Electrophilic substitution in the benzene ring of indole compounds (Review). Chem Heterocycl Compd 16, 887–903 (1980). https://doi.org/10.1007/BF00742835

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Keywords

  • Benzene
  • Organic Chemistry
  • Indole
  • Pyrrole
  • Benzene Ring