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Direct amination of ceramidonines

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Direct amination of ceramidonine, 2-methylceramidonine, and 2-methyl-7-chloroceramidonine is investigated. It is shown that aromatic amines react with ceramidonines at 120°–150° C, to give 6- and 8-arylaminoceramidonines, the amino group entering preferentially at position 6. Strongly basic amines, (cyclohexylamine, methylamine) react with 2-methylceramidonines under mild conditions, giving mainly 8 -aminoceramidonines.

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Authors and Affiliations

  1. Novosibirsk Institute of Organic Chemistry, Siberian Division, AS USSR, USSR

    R. P. Shishkina & E. P. Fokin

Authors
  1. R. P. Shishkina
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  2. E. P. Fokin
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Additional information

The nomenclature used is that of the Ring Index, Patterson and Capell, 1960.

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Shishkina, R.P., Fokin, E.P. Direct amination of ceramidonines. Chem Heterocycl Compd 2, 306–311 (1967). https://doi.org/10.1007/BF00742375

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  • DOI: https://doi.org/10.1007/BF00742375

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