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“Keratolytic” effect of salicylic acid

Archives of Dermatological Research volume 257, pages 293–297 (1977)Cite this article

Summary

The “keratolytic” effect of salicylic acid was examined in guinea-pig skin. Using a fluorescent staining method the str. corneum cells could be seen to rapidly become detached. The cellular walls remained unchanged. This drug therefore appears to primarily reduce the intercellular cohesiveness of the horny cells.

Zusammenfassung

Der sogenannte keratolytische Effekt von Salicylsäure an der Hornschicht wurde unter Verwendung der FITC-Darstellungsmethode untersucht. Es zeigte sich, daß die Hornzellen ohne Verlust der Membranfluorescenz abgelöst werden. Die Zellen bleiben intakt. Salicylsäure wirkt somit im Bereiche der intercellulären Verkittung. Neben der „Keratolyse“ zeichnet sich Salicylsäure durch fehlende Epidermotoxicität aus.

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References

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Authors and Affiliations

  1. Department of Dermatology, University of Kiel, Schittenhelmstraße 7, D-2300, Kiel 1, Germany

    C. Huber & E. Christophers

Authors
  1. C. Huber
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  2. E. Christophers
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Huber, C., Christophers, E. “Keratolytic” effect of salicylic acid. Arch. Derm. Res. 257, 293–297 (1977). https://doi.org/10.1007/BF00741846

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  • DOI: https://doi.org/10.1007/BF00741846

Keywords

  • Public Health
  • Salicylic Acid
  • Staining Method
  • Fluorescent Staining
  • Cellular Wall