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Vitiliginous achromia with malignant melanoma

Tyrosinase Activity and Ultrastructural Study of Achromic and Normal Skin

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Summary

Vitiliginous achromia with malignant melanoma shows some discrepancies with vitiligo. In both achromic and normal skin, four bands A, B, C, D of tyrosinase activity are observed; in vitiligo only bands A and B appear. Ultrastructural findings in achromic skin are similar in both conditions. But in achromia with malignant melanoma, melanocyte abnormalities are also present in normal skin and the role of immunological factors is discussed.

Zusammenfassung

Die vitiliginösen Herde beim malignen Melanom zeigen Unterschiede in der Disc-Elektrophorese der Dopa-Oxydase-Banden zur Vitiligo, während bei der Vitiligo nur die Banden A und B erscheinen, liegen in der aromatischen und normalen Haut des malignen Melanoms 4 Banden, A, B, C, D vor. Die ultrastrukturellen Befunde entsprechen sich allerdings, doch werden beim malignen Melanom Abnormalitäten von Melanocyten auch in der normalen Haut aufgefunden und in Beziehung zu immunologischen Prozessen gebracht.

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Authors and Affiliations

  1. Department of Dermatology, University of Lyon, Médical School, Place d'Arsonval, F-69374, Lyon, Cedex 2, France

    H. Perrot, J. P. Ortonne & D. Schmitt

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  1. H. Perrot
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  2. J. P. Ortonne
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  3. D. Schmitt
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The technical assistance of Miss D. Germain is gratefully acknowledged

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Perrot, H., Ortonne, J.P. & Schmitt, D. Vitiliginous achromia with malignant melanoma. Arch. Derm. Res. 257, 247–253 (1977). https://doi.org/10.1007/BF00741840

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  • DOI: https://doi.org/10.1007/BF00741840

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