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Endocrine differentiation in inflamed urinary bladder epithelium with metaplastic changes

Virchows Archiv A volume 412, pages 267–272 (1988)Cite this article

Summary

Several types of metaplasia can occur in human bladder epithelium under certain pathological conditions. We investigated 65 cases of cystitis, associated with different types of metaplasia, for the presence of endocrine cells, using histochemical and immunocytochemical methods. Tissues were obtained at cystoscopy and were routinely fixed in 10% buffered formalin. Endocrine cells were demonstrated, between the epithelial cells, in 40 out of 50 cases of cystitis glandularis or cystica. These cells were positive by the Grimelius' silver impregnation technique and were immunoreactive for protein gene product (PGP 9.5), a new general neuroendocrine marker, chromogranin and serotonin. No endocrine cells were detected in any of the specimens of normal epithelium nor those showing squamous metaplasia. Eighteen of these cases showed prominent nerve bundles in the sub-epithelial tissue, as revealed by PGP immunoreactivity.

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Affiliations

  1. Department of Histochemistry, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road, W12 OHS, London, UK

    Q. A. Hamid, A. E. Bishop & J. M. Polak

  2. Department of Histopathology, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road, W12 OHS, London, UK

    A. M. Flanagan, M. Stratton & D. J. Evans

  3. The Bland-Sutton Institute of Pathology, The Middlesex Hospital Medical School, W1P 7PN, London, UK

    J. Rode

  4. Department of Histopathology, The Royal Free Hospital, NW3 2QG, London, UK

    A. P. Dhillon

Authors
  1. Q. A. Hamid
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  2. J. Rode
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  3. A. M. Flanagan
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  4. A. P. Dhillon
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  5. A. E. Bishop
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  6. M. Stratton
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  7. D. J. Evans
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  8. J. M. Polak
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Hamid, Q.A., Rode, J., Flanagan, A.M. et al. Endocrine differentiation in inflamed urinary bladder epithelium with metaplastic changes. Vichows Archiv A Pathol Anat 412, 267–272 (1988). https://doi.org/10.1007/BF00737151

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  • DOI: https://doi.org/10.1007/BF00737151

Key words

  • Cystitis
  • Metaplasia
  • Endocrine cells
  • Urinary bladder