Summary
Two cases of osteoclast-type giant cell tumour of the pancreas (OGTP) are presented and compared with similar tumours of other locations and pancreatic carcinomas. One of the tumours was analyzed by immunohistochemical methods. The mononuclear stromal cells and osteoclast-like giant cells, which characterize this very rare neoplasm, reacted with an antibody against vimentin, but were not decorated by antibodies against lysozyme, alpha-1-ACHT, alpha-1-AT. Pleomorphic mononuclear cells in osteoid additionally contained osteonectin and could thus be identified as osteoblasts. Only the tumour glands stained positively with panepithelial keratin antibodies and antibodies against the keratin polypeptides 7, 18, 19. These results demonstrate for the first time the mesenchymal differentiation of the OGTP, which in some cases is also able to form epithelial structures. The immunohistochemical reactions and the characteristic morphology of the tumour show the OGTP to be an entity which must be differentiated from pancreatic carcinoma, especially from its giant cellular subtype.
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References
Andreola S, Lombardi L, Scurelli A, Bersiga A (1985) Osteoclastoma-like giant-cell tumor of the liver. Case Report. Tumori 71:615–620
Alguacil-Garcia A, Weiland LH (1977) The histologic spectrum prognosis and histogenesis of the sarcomatoid carcinoma of the pancreas. Cancer 39:1181–1189
Alguacil-Garcia A, Alonso A, Pettigrew NM (1984) Sarcomatoid carcinoma (so-called pseudosarcoma) of the larynx simulating malignant giant cell tumor of soft parts. Am J Clin Pathol 82:340–343
Balogh K, Wolbarsht RL, Federman M, O'Hara CJ (1985) Carcinoma of the parotid gland with osteoclastlike giant cells. Arch Pathol Lab Med 109:756–761
Berendt RC, Shnitka TK, Wiens E, Manickavel V, Jewell LD (1987) The osteoclast-type giant cell tumor of the pancreas. Arch Pathol Lab Med 111:43–48
Bosslet K, Lüben G, Schwarz A, Hundt E, Harthus HP, Seiler FR, Muhrer C, Klöppel G, Kayser K, Sedlacek HH (1985) Immunohistochemical localization and molecular characteristics of three monoclonal antibody-defined epitopes detectable on carcinoembryonal antigen (CEA) Int J Cancer 36:75–84
Cubilla AL, Fitzgerald PJ (1984) Tumors of the exocrine pancreas. Atlas of Tumor Pathology. Second Series, Fascicle 19. Armed Forces Institute of Pathology Washington, DC pp 155–167
Debus E, Weber K, Osborn M (1983) Monoclonal antibodies to desmin, the muscle-specific intermediate filament protein. EMBO J 2:2305–2312
Debus E, Moll R, Franke WW, Weber K, Osborn M (1984) Immunohistological distinction of human carcinomas by cytokeratin typing with monoclonal antibodies. Am J Pathol 114:121–130
Eusebi V, Scott AM, Govoni E, Rosai J (1984) Giant cell tumor of major salivary glands: Report of three cases, one occurring in association with a malignant mixed tumor. Am J Clin Pathol 81:666–675
Freund U (1973) Pleomorphic giant cell tumor of the pancreas. Isr Med Sci 9:84–88
Guillan RA, McMahon J (1973) Pleomorphic adenocarcinoma of the pancreas. Am J Gastroenterol 60:379–386
Hsu SM, Raine L, Fanger H (1981) Use of avidin-biotin peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochm 29:577–580
Jeffrey I, Crow J, Ellis BW (1983) Osteoclast-type giant cell tumour of the pancreas. J Clin Pathol 36:1165–1170
Jundt G, Berghäuser KH, Termine JD, Schulz A (1987) Osteonectin - a differentiation marker of bone cells. Cell Tissue Res 248:409–415
Klöppel G, Held G, Morohoshi T, Seifert G (1982) Klassification exokriner Pankreastumoren. Pathologe 3:319–328
Nagle RB, Moll R, Weidauer H, Nemetschek H, Franke WW (1985) Different patterns of cytokeratin expression in the normal epithelia of the upper respiratory tract. Differentiation 30:130–140
Osborn M, Debus E, Weber K (1984) Monoclonal antibodies specific for vimentin. Eur J Cell Biol 34:137
Osborn M, van Lessen G, Weber K, Klöppel G, Altmannsberger M (1986) Differential diagnosis of gastrointestinal carcinomas by using monoclonal antibodies specific for individual keratin polypeptides. Lab invest 55:497–504
Overbeck von J, Stähli C, Gudat F, Carmann H, Lautenschlager C, Dürrmüller U, Takacs B, Miggiano V, Staehelin T, Heitz PU (1985) Immunohistochemical characterization of an anti-epithelial monoclonal antibody (mAB lu-5). Virchows Arch A (Pathol Anat) 407:1–12
Posen JA (1981) Giant cell tumor of the pancreas of the osteoclastic type associated with a mucous secreting cystadenocarcinoma. Human Pathol 12:944–947
Robinson L, Damjenow I, Brezina P (1977) Multinucleated giant cell neoplasm of pancreas. Arch Pathol Lab Med 101:590–593
Rosai J (1968) Carcinoma of pancreas simulating giant cell tumor of bone. Cancer 22:333–344
Schajowicz F (1981) Giant-cell tumor (osteoclastoma). In: Schajowicz F: Tumors and tumorlike lesions of bone and joints. Springer, New York Heidelberg Berlin, pp 205–242
Schulz A (1980) Ultrastrukturpathologie der Knochentumoren. G. Fischer, Stuttgart, New York
Stein H, Gatter K, Asbahr H, Mason DY (1985) Use of freeze-dried paraffin-embedded sections for immunohistologic staining with monoclonal antibodies. Lab invest 52:676–683
Sternberger LA (1979) Immunocytochemistry, 2nd ed. John Wiley, New York
Termine JD, Kleinman HK, Whitson SW, Conn KM, McGarvey ML, Martin GR (1981) Osteonectin, a bone-specific protein linking mineral to collagen. Cell 26:99–105
Toelle HG, Weber K, Osborn M (1985) Microinjection of monoclonal antibodies specific for one intermediate filament protein in cells containing multiple keratins allow insight into composition of particular 10 nm filaments. Eur J Cell Biol 38:234–240
Trepeta RW, Mathur B, Lagin S, LiVolsi VA (1981) Giant cell tumor (“osteoclastoma”) of the pancreas: A tumor of epithelial origin. Cancer 48:2022–2028
Viac J, Reano A, Brochier J, Staquet MJ, Thivolet J (1983) Reactivity pattern of a monoclonal anti-keratin antibody (KL 1). J Invest Dermatol 81:351–354
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Fischer, H.P., Altmannsberger, M. & Kracht, J. Osteoclast-type giant cell tumour of the pancreas. Vichows Archiv A Pathol Anat 412, 247–253 (1988). https://doi.org/10.1007/BF00737149
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DOI: https://doi.org/10.1007/BF00737149