Virchows Archiv A

, Volume 406, Issue 2, pp 197–201 | Cite as

Phagocytosis of mast cell granules by fibroblasts of the human gingiva

  • Yasunori Takeda


Mast cell granules have been detected ultrastructurally within the cytoplasm of fibroblasts in fibrous hyperplastic lesion of the human gingiva. This finding is interpreted as phagocytosis of mast cell granules by fibroblasts. It is estimated that phagocytosis of mast cell granules occurred in four to six per cent of the fibroblasts. The result of present study suggests that mast cells play some role in fibroblast activity not only in animals as reported previously, but also in human connective tissue.

Key words

Mast cells Fibroblasts Phagocytosis Human gingiva 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Alexander P (1979) The mast cell: In: Pepys J, Edwards A (eds.) its role in health and disease. Pitman Med Publ Co, London, p 137Google Scholar
  2. Arnold W, Hath F (1978) Electron microscopic findings in four cases of nasopharyngeal fibroma. Virchows Arch [Pathol Anat] 379:285–298Google Scholar
  3. Azizkhan RG, Azizkhan JC, Zetter BR, Folkman J (1980) Mast cell haparin stimulates migration of capillary endothelial cells in vitro. J Exp Med 152:931–944Google Scholar
  4. Barnett ML (1973) Mast cells in the epithelial layer of human gingiva. J Ultrastruct Res 43:247–255Google Scholar
  5. Boswell RN, Austen KF, Geotzl EJ (1978) Intermediate molecular weight eosinophil chemotactic factors in rat peritoneal mast cells: Immunologic release, granule association, and demonstration of structural heterogeneity. J Immunol 120:15–20Google Scholar
  6. Greenberg G, Burnstock G (1983) A novel cell-to-cell interaction between mast cells and other cell types. Exp Cell Res 147:1–13Google Scholar
  7. Higginbotham RD, Dougherty TF, Jee WSS (1956) Fate of shed mast cell granules. Proc Soc Exp Biol Med 92:256–261Google Scholar
  8. Janin-Mercier A, Bourges M, Fonck-Cussac Y, Bussieres JL, Leblanc B, Delage J (1981) Eosinophilic fasciitis. Ultrastructural study of an early biopsied case. Virchows Arch [Pathol Anat] 394:177–184Google Scholar
  9. Lindahl U, Pertoft H, Seljelid R (1979) Uptake and degradation of mast-cell granules by mouse peritoneal macrophages. Biochem J 182:189–193Google Scholar
  10. Norrby K (1981) On the 48/80-induced secretion of tissue mast cells and its mitogenic effect on nearby cells in the intact rat. Virchows Arch [Cell Pathol] 38:57–65Google Scholar
  11. Norrby K, Eneström S (1984) Cellular and extracellular changes following mast-cell secretion in avascular rat mesentery. An electron-microscopic study. Cell Tissue Res 235:339–345Google Scholar
  12. Rao PVS, Friedman MM, Atkins FM, Metcalfe DD (1983) Phagocytosis of mast cell granules by cultured fibroblasts. J Immunol 130:341–349Google Scholar
  13. Roszkowski W, Plaut M, Lichtenstein LM (1977) Selective display of histamine receptors on lymphocytes. Science 195:683–685Google Scholar
  14. Sandberg N (1962) Accelerated collagen formation and histamine. Nature 194:183Google Scholar
  15. Tannenbaum S, Oertel H, Henderson W, Kaliner MA (1980) The biologic activity of mast cell granules. I. Elicitation of inflammatory responses in rat skin. J Immunol 125:325–335Google Scholar
  16. Watanabe S, Watanabe K, Ohishi T, Aiba M, Kageyama K (1974) Mast cells in the rat alveolar septa undergoing fibrosis after ionizing irradiation. Lab Invest 31:555–567Google Scholar

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • Yasunori Takeda
    • 1
  1. 1.Department of Oral Pathology, School of DentistryIwate Medical UniversityMorioka, IwateJapan

Personalised recommendations