Advertisement

Cytotechnology

, Volume 5, Supplement 1, pp 55–56 | Cite as

Methylation state of the human HLA-DRa gene in transgenic mice

  • Giordana Feriotto
  • Laura Pozzi
  • Francesco Deledda
  • Rafaella Barbieri
  • Roberta Piva
  • Claudio Nastruzzi
  • Alessandra Ciucci
  • Pier Giorgio Natali
  • Patrizio Giacomini
  • Roberto Gambari
Selected Paper
  • 17 Downloads

Abstract

We describe the tissue-specific expression and the reconstitution of the canonical methylation state of the human HLA-DRa gene in transgenic mice.

Keywords

Methylation Transgenic Mouse Methylation State 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. [1]
    Froham M.A. and Martin G.R. (1989) Cut, Paste and Save: New Approaches to Altering Specific Genes in Mice. Cell 56, 145–147.Google Scholar
  2. [2]
    Shamboeck A., Korman A.J., Kamb A. and Strominger J.L. (1983) Organization and transcriptional unit of a human class II histocompatibility antigen: HLA-DR heavy chain. Nucl. Acids Res. 11, 8663–8671.Google Scholar
  3. [3]
    Saiki R.K., Scharf S., Faloona F., Erlich H.A. and Arnheim N. (1985) Enzymatic amplification of β-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science 230, 1350–1354.Google Scholar
  4. [4]
    Barbieri R., Nastruzzi C., Volinia S., Villa M., Piva R., Giacomini P., Natali P.G. and Gambari R. (1990) Methylation pattern of the HLA-DRa gene in human tissues. J. of Immunogenetics 17, 51–66.Google Scholar
  5. [5]
    vanEwijk W., Ron Y., Monaco J., Kappler J., Marrack P., LeMeur M., Durand B., Benoist C. and Mathis D. (1988) Compartmentalization of MHC Class II Gene Expression in Transgenic Mice. Cell 53, 357–370.Google Scholar

Copyright information

© Kluwer Academic Publishers 1991

Authors and Affiliations

  • Giordana Feriotto
    • 1
  • Laura Pozzi
    • 2
  • Francesco Deledda
    • 1
  • Rafaella Barbieri
    • 1
  • Roberta Piva
    • 1
  • Claudio Nastruzzi
    • 1
  • Alessandra Ciucci
    • 3
  • Pier Giorgio Natali
    • 3
  • Patrizio Giacomini
    • 3
  • Roberto Gambari
    • 1
    • 4
  1. 1.Biochemistry InstituteFerrara UniversityRomeItaly
  2. 2.Human Biopathology DepartmentRome UniversityRomeItaly
  3. 3.Immunology LaboratoryRegina Elena InstituteRomeItaly
  4. 4.Biotechnology CenterFerraraItaly

Personalised recommendations