Abstract
The effect ofC. parvum and/or levamisole on tumour growth and spontaneous dissemination was tested in two tumour-host systems, melanoma B16 and LLT in C57BL/6J mice.C. parvum inhibited the growth of LLT and its dissemination to the lungs and the growth of B 16 in females in one of the two sub-strains of mice used. Levamisole stimulated the growth of B 16 in females in one sub-strain and in both sexes in the other sub-strain of mice. The growth of LLT was not influenced by levamisole but its dissemination to lymph nodes was facilitated. The growth-stimulating effect of levamisole was abrogated byC. parvum in the mice treated with both agents in combination. It is concluded that the effects of non-specific immunomodulators on tumour growth and spread can vary between sub-strains of the same inbred strain of mice bred at different laboratories.
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Boeryd, B., Benktson, A. The growth and spontaneous dissemination of melanoma B16 and Lewis lung tumour in two sub-strains of C57BL/6J mice treated withCorynebacterium parvum and/or levamisole. Clin Exp Metast 1, 289–295 (1983). https://doi.org/10.1007/BF00736411
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DOI: https://doi.org/10.1007/BF00736411