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The influence of intramedullary nailing upon the development of metastases in the treatment of an impending pathological fracture: an experimental study

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Abstract

An experimental model has been developed in which the effects of a pathological fracture and intramedullary nailing on metastatic spread have been investigated. The endpoint used was the production of lung metastases in rats inoculated intracortically with a rhabdomyosarcoma. We have found that a pathological fracture markedly increases the incidence of lung metastases and that intramedullary nailing, by decreasing the incidence of fractures, decreases the incidence of lung metastases. The surgical procedure itself does not increase the incidence significantly. It is concluded that in metastatic disease prophylactic nailing of an impending pathological fracture is the treament of choice.

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References

  1. Barendsen, G. W., Janse, H. G., Deys, B. F., andHollander, C. F., 1977, Comparison of growth characteristics of experimental tumours and derived cell cultures.Cell and Tissue Kinetics,10, 469–475.

    Google Scholar 

  2. Bouma, W. H., 1981, The surgical treatment of pathological and impending pathological fractures. Dissertation, Amsterdam.

  3. Bremner, R. A., andJelliffe, A. M., 1958, The management of pathological fracture of the major long bones from metastatic cancer.Journal of Bone and Joint Surgery,40B, 652–659.

    Google Scholar 

  4. Devas, M. B., Dickson, J. W., andJelliffe, A. M., 1956, Pathological fractures: treatment by internal fixation and irradiation.The Lancet, 484–487.

  5. Douglass, H. O., Shukla, S. K., andMindell, E., 1976, Treatment of pathological fractures of long bones excluding those due to breast cancer.Journal of Bone and Joint Surgery,58A, 1055–1061.

    Google Scholar 

  6. Fidler, M., andStollard, G., 1977, The management of secondary neoplastic deposits in long bones by prophylactic internal fixation.Archivum chirurgicum neerlandicum, 177–185.

  7. Francis, K. C., 1960, Prophylactic internal fixation of metastatic osseous lesions.Cancer,13, 75–76.

    Google Scholar 

  8. Haase, W., 1943, Der Küntscher-Nagel bei spontanfraktur durch hypernephrommetastase.Zentralblatt für Chirurgie,35, 1266–1268.

    Google Scholar 

  9. Harrington, K. D., Johnston, J. O., Turner, R. H., andGreen, D. L., 1972, The use of methylmethacrylate as an adjunct in the internal fixation of malignant neoplastic fractures.Journal of Bone and Joint Surgery,54A, 1665–1676.

    Google Scholar 

  10. Hoare, J. R., 1968, Malignant neoplastic fractures. Pathologic fractures.Journal of Bone and Joint Surgery,50B, 232.

    Google Scholar 

  11. Junge, H., 1951, Marknagelung in abnorm brüchigen Knochen.Hefte zur Unfallheilkunde,40, 60–70.

    Google Scholar 

  12. Katzner, M., Petit, R., andSchvingt, E., 1974, Traitement chirurgical des métastases et des fractures metastatiques des os longs.Revue de Chirurgie orthopédique,60, 387–400.

    Google Scholar 

  13. Knutson, C. O., andSpratt, J. S., 1970, The natural history and management of mammary cancer metastatic to the femur.Cancer,26, 1199–1203.

    Google Scholar 

  14. Madden, R. E., andKarpas, C. M., 1967, Arrest of circulating tumor cells versus metastases formation.Archives of Surgery,94, 307–312.

    Google Scholar 

  15. Peltier, L. F., 1951, Theoretical hazards in the treatment of pathologic fractures by the Küntscher intramedullary nail.Surgery,29, 466–471.

    Google Scholar 

  16. Peltier, L. F., andNice, C. M., 1951, Further observations upon intramedullary pressures, during the fixation of fractures by Küntscher's method.Surgery,30, 964–966.

    Google Scholar 

  17. Rieder, W., andSchumann, G., 1943, Unsere Indikation zur Marknagelung der langen röhrenknochen.Deutsche Zeitschrift für Chirurgie,257, 415–444.

    Google Scholar 

  18. Rinecker, H., andDölle, V., 1975, Zur therapie maligner extremitätenfrakturen,Münchener medizinische Wochenschrift,45, 1791–1796.

    Google Scholar 

  19. Stoffella, R., Vécsei, V., Scharf, W., andKutscha-Lissberg, E., 1980, Operations indikation und operation smethoden bei pathologischen frakturen der langen röhrenknochen.Unfallheilkunde,83, 89–96.

    Google Scholar 

  20. Tachdjian, M. O., andCompere, C. L., 1959, Pathologic fractures of the hip.SGO,109, 13–26.

    Google Scholar 

  21. Werner, W., 1970, Das Vorgehen bei skelettmetastasen.Beitrage zür Orthopaedie und Traumatologie,1, 1–4.

    Google Scholar 

  22. Zickel, R. E., andMouradian, W. H., 1976, Intramedullary fixation of pathological fractures and lesions of the subtrochanteric region of the femur.Journal of Bone and Joint Surgery,58A, 1061–1066.

    Google Scholar 

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Authors and Affiliations

  1. Department of Surgery, Zuiderziekenhuis, Radiotherapeutic Institute, Rotterdam and the Radiobiological Institute TNO, Rijswijk, The Netherlands

    W. H. Bouma, J. H. Mulder & W. C. J. Hop

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  1. W. H. Bouma
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  2. J. H. Mulder
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  3. W. C. J. Hop
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Bouma, W.H., Mulder, J.H. & Hop, W.C.J. The influence of intramedullary nailing upon the development of metastases in the treatment of an impending pathological fracture: an experimental study. Clin Exp Metast 1, 205–212 (1983). https://doi.org/10.1007/BF00736404

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  • DOI: https://doi.org/10.1007/BF00736404

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