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Studies on the histochemical “leucine aminopeptidase” reaction

II. Chemical and histochemical comparison of the enzymatic and environmental factors involved

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Zeitschrift für Zellforschung und mikroskopische Anatomie Abt. Histochemie Aims and scope Submit manuscript

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References

  • Bitensky, L.: The demonstration of lysosomes by the controlled temperature freezing-sectioning method. Quart. J. micr. Sci.103, 205–209 (1962).

    Google Scholar 

  • Burstone, M. S.: The relationship between fixation and techniques for the histochemical localization of hydrolytic enzymes. J. Histochem. Cytochem.6, 322–339 (1958).

    Google Scholar 

  • —— Enzyme histochemistry and its application in the study of neoplasms. New York: Academic Press 1962.

    Google Scholar 

  • —— andJ. E. Folk: Histochemical demonstration of Aminopeptidase. J. Histochem. Cytochem.4, 217–226 (1956).

    Google Scholar 

  • Cassens, R. G., E. J. Briskey andW. G. Hoekstra: Electron microscopy of post-mortem changes in porcine muscle. Nature (Lond.)197, 1119–1120 (1963).

    Google Scholar 

  • Duve, C. de: Lysosomes, a new group of cytoplasmic particles, In: Subcellular particles, p. 128–159. Washington: American Physiological Society 1959.

    Google Scholar 

  • Fruton, J. S., andM. J. Mycek: Studies on beef spleen cathepsin C. Arch. Biochem.65, 11–20 (1956).

    Google Scholar 

  • Goldbarg, J. A., andA. M. Rutenburg: The colorimetric determination of leucine amino-peptidase in urine and serum of normal subjects and patients with cancer and other diseases. Cancer (Philad.)11, 283–291 (1958).

    Google Scholar 

  • Green, M. N., K.-C. Tsou, R. Bressler andA. M. Seligman: The colorimetric determination of leucine aminopeptidase activity withl-leucyl-naphthylamide hydrochloride. Arch. Biochem.57, 458–474 (1955).

    Google Scholar 

  • Hannibal, M. J., andM. M. Nachlas: Further studies on the lyo and desmo components of several hydrolytic enzymes and their histochemical significance. J. biophys. biochem. Cytol.5, 279–288 (1959).

    Google Scholar 

  • Holmberg, B.: On the permeability to lissamine green and other dyes in the course of cell injury and cell death. Exp. Cell Res.22, 406–414 (1961).

    Google Scholar 

  • Holt, S. J.: Factors governing the validity of staining methods for enzymes and their bearing upon the Gomori acid phosphatase technique. Exp. Cell Res., Suppl.7, 1–27 (1959).

    Google Scholar 

  • Monis, B., M. M. Nachlas andA. M. Seligman: Study of leucine aminopeptidase in neoplastic and inflammatory tissues with a new histochemical method. Cancer (Philad.)12, 601–608 (1959).

    Google Scholar 

  • Nachlas, M. M., D. T. Crawford andA. M. Seligman: The histochemical demonstration of leucine aminopeptidase. J. Histochem. Cytochem.5, 264–278 (1957).

    Google Scholar 

  • —— andA. M. Seligman: Influence of chemical structure on the rate of azo coupling and its significance in histochemical methodology. J. Histochem. Cytochem.7, 50–65 (1959).

    Google Scholar 

  • Nayyar, S. N., andD. Glick: Studies in histochemistry XXXI. A method for the determination of protein in millimicrogram quantities. J. Histochem. Cytochem.2, 282–290 (1954).

    Google Scholar 

  • Ottoson, R., andB. Sylvén: Changes in the dipeptidase and acid proteinase activities in blood plasma of mice carrying ascites tumors. Arch. Biochem.87, 41–47 (1960).

    Google Scholar 

  • Patterson, E. K., S.-H. Hsiao andA. Keppel: Studies on dipeptidases and aminopeptidases. I. Distinction between leucine aminopeptidase and enzymes which hydrolysel-leucyl-β-naphthylamide. J. biol. Chem. (in press 1963).

  • —— andS.-H. Hsiao: Evidence from purification procedures that the enzyme which hydrolyzesl-leucyl-β-naphthylamide is not the classical leucine aminopeptidase. J. Histochem. Cytochem.9, 609 (1961).

    Google Scholar 

  • Planta, R. J., andM. Gruber: Specificity of cathepsin C. Biochem. biophys. Acta (Amst.)53, 443–444 (1961).

    Google Scholar 

  • Smith, E. L., andD. H. Spackman: Leucine aminopeptidase. V. Activation, specificity and mechanism of action. J. biol. Chem.212, 271–299 (1955).

    Google Scholar 

  • Snoke, J. E., andH. Neurath: The proteolytic activity of striated rabbit muscle. J. biol. Chem.187, 127–135 (1950).

    Google Scholar 

  • Sylvén, B.: Effects of freezing and drying compared with common fixation procedures. In: Freezing and Drying, p. 1–8. London: Church Army Press 1952.

    Google Scholar 

  • —— Factors concerned in invasiveness and destructiveness at the tumor-host interzone, p. 635–655. Henry Ford Hosp. Symposia. Boston: Little, Brown & Co. 1962.

    Google Scholar 

  • —— andI. Bois: Studies on the histochemical „leucine aminopeptidase“ reaction. I. Identity of the enzymes possibly involved. Histochemie3, 65–78 (1962).

    Google Scholar 

  • --, andH. Malmgren: The histological distribution of proteinase and peptidase activity in solid tumor transplants. Act radiol. (Stockh.), Suppl.154 (1957).

  • —— andO. Snellman: A new metal-dependent enzyme present in cathepsin C preparations. Biochim. biophys. Acta (Amst.)65, 350–353 (1962).

    Google Scholar 

  • Weiss, L., andJ. A. Armstrong: Structural changes in mammalian cells associated with cooling to —70°C. J. biophys. biochem. Cytol.7, 673–677 (1960).

    Google Scholar 

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Sylvén, B., Bois, I. Studies on the histochemical “leucine aminopeptidase” reaction. Histochemie 3, 341–353 (1963). https://doi.org/10.1007/BF00736395

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