Abstract
The effect of 50% convulsant (CD50) and 50% lethal (LD50) doses of lidocaine, bupivacaine and pentylenetetrazol were determined in mice stressed by paradoxical sleep deprivation (PSD). The results showed a reduced mortality after high doses of local anesthetics and decreased seizure susceptibility induced by bupivacaine after 48 h and 72 h of PSD. On the other hand this stressful manipulation increased the susceptibility to pentylenetetrazol-induced convulsions. These data may suggest a different mechanism of action for these drugs. Possible alterations in drug metabolism or on aminergic transmission after PSD may be involved in the protection to the toxic effect of the local anesthetics.
Similar content being viewed by others
References
Bennett DR (1963) Sleep deprivation and major motor convulsions. Neurology 13:953–958
Ciarlone AE (1981) Alteration of lidocaine or procaine-induced convulsions by manipulation of brain amines. J Dent Res 60:182–186
Cohen HB, Dement WC (1965) Sleep: changes in threshold to electroconvulsive shock in rats after deprivation of “paradoxical” phase. Science 150:1318–1319
Cohen HB, Dement WC (1970) Prolonged tonic convulsions in REM deprived mice. Brain Res 22:421–422
De Jong RH (1978) Toxic effects of local anesthetics. JAMA 239:1166–1168
Fishbein W (1970) Interference with conversion of memory from short-term to long-term storage by partial sleep deprivation. Commun Behav Biol 5:171–175
Forbes WB, Stern WC, Tracy CA, Resnick O, Morgane PJ (1978) Effect of chronic protein malnutrition on experimentally induced seizures in the rat. Exp Neurol 62:475–481
Frank GB, Sanders HD (1963) A proposed common mechanism of action for general and local anesthetics in the central nervous system. Br J Pharmacol 21:1–9
Gabriel NN, Soliman KFA (1983) Effect of stress on the acetylcholinesterase activity of the hypothalamus-pituitary-adrenal axis in the rat. Horm Res 17:43–48
Gunderson CH, Dunne PB, Feyer TL (1973) Sleep deprivation seizures. Neurology 23:678–686
Kafka MS, Wirz-Justice A, Naber D, Moore RY, Benedito MA (1983) Circadian rhythms in rat brain neurotransmitter receptors. Fed Proc 42:2796–2801
Litchfield JT, Wilcoxon F (1949) A simplified method of evaluating dose-effect experiments. J Pharmacol Exp Ther 96:99–113
Lutsch EF, Morris RW (1967) Circadian periodicity in susceptibility to lidocaine hydrochloride. Science 156:100–103
Mogilnicka E (1981) REM sleep deprivation changes behavioral response to catecholaminergic and serotonergic receptor activation in rats. Pharmacol Biochem Behav 15:149–151
Naik SR, Kelkar MR, Sheth UK (1977) Effect of chronic stress on brain cholinesterase. Indian J Med Res 66:513–516
Swinyard EA, Radhakrisham N, Goodman LS (1962) Effect of brief restraint on the convulsive threshold of mice. J Pharmacol Exp Ther 138:337–342
Swinyard EA, Miyara JT, Clark LD, Goodman LS (1963) The effect of experimentally induced stress on pentylenetetrazol seizure threshold in mice. Psychopharmacologia 4:343–353
Tufik S, Lindsey CJ, Carlini EA (1978) Does REM sleep-deprivation induce a supersensitivity of dopaminergic receptors in the rat brain. Pharmacology 16:98–105
Author information
Authors and Affiliations
Additional information
This work was supported by Pro-Reitoria de Pesquisa e Pos-Graduacao UFRN and CNPq
Holder of fellowship from CAPES
Holder of research fellowship from CNPq
Rights and permissions
About this article
Cite this article
Vale, N.B., Leite, J.R. Decreased susceptibility to local anesthetics-induced convulsions after paradoxical sleep deprivation. Psychopharmacology 94, 138–140 (1988). https://doi.org/10.1007/BF00735895
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00735895