Abstract
A radioimmunoassay (RIA) was developed for the quantification of caffeine in saliva. The mean salivary caffeine level for this sample of 40 full-term, AGA, healthy 1–2 day old human neonates was consistent with levels reported in previous studies. Salivary caffeine was significantly correlated with the number of state changes and startles observed during administration of the Brazelton Neonatal Behavior Assessment Scale. There was also a nonsignificant trend correlating salivary caffeine with visual orienting and consolability.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Berlin CM (1981) Excretion of the methylxanthines in human milk. Semin Perinatol 5:389–394
Brackbill Y, Kane J, Manniello R, Abramson D (1974) Obstetrical meperidine usage and assessment of neonatal status. Anesthesiology, 40:116–120
Brazelton TB (1973) Neonatal behavior assessment scale. In: Clinics in developmental Medicine, N. 50. Lippincott, Philadelphia
Cook CE, Tallent CR, Emerson EW, Myers MW, Kepler JA, Taylor GF, Christensen HD (1976) Caffeine in plasma and saliva by a radioimmunoassay procedure. J Pharmacol Exp Ther 199:679–686
Dubowitz L, Dubowitz V, Goldberg C (1970) Clinical assessment of gestational age in the newborn infant. J Pediatr 77:1–10
Fuju T, Nishimura H (1972) Adverse effects of prolonged administration of caffeine on the rat fetus. Toxicol Appl Pharmacol 22:449–457
Hill RM (1973) Drugs ingested by pregnant women. Clin Pharmacol Ther 14:654–659
Horning MG, Statton C, Nowlin J, Wilson A, Horning EC, Hill RM (1973) Placental transfer of drugs. In: Boreus L (ed) Fetal Pharmacology. Raven Press, New York
Horning MG, Butler CM, Nowlin J, Hill RM (1975) Drug metabolism in the human neonate. Life Sci 16:651–671
Howell J, Clozel M, Aranda JV (1981) Adverse effects of caffeine and theophylline in the newborn infant. Semin Perinatol 5:359–369
Hronsky SL, Emory EK (1987) Neurobehavioral effects of caffeine on neonatal behavior. Infant Behavior and Development 10:61–80
Jacobson S, Fein G, Jacobson J, Schwartz P, Dowler J (1984) Neonatal correlates of prenatal exposure to smoking, caffeine and alcohol. Infant Behavior and Development 7:253–265
Kirkinen P, Jouppila P, Koivula A, Vouri J, Puuka M (1983) The effect of caffeine on placental and fetal blood flow in human pregnancy. Am J Obstet Gynecol 147:939–942
Lane JD, Williams RB (1985) Caffeine affects cardiovascular response to stress. Psychophysiology 22:648–655
Lester B, Als H, Brazelton T (1982) Regional obstetric anesthesia and newborn behavior. An reanalysis toward synergistic effects. Child Dev 53:687–692
Marks V, Kelly JF (1973) Absorption of ceffeine from tea, coffee, and coca cola. Lancet I:827
Mirkin BL (1973) Drug distribution in pregnancy. In: Boreus L (ed) Fetal pharmacology. Raven, New York
Mirkin BL, Singh S (1976) Placental transfer of pharmacologically active molecules. In: Mirkin BL (ed) Perinatal pharamacology and therapeutics. Academic, New York
Morris MB, Weinstein L (1981) Caffeine and the fetus: Is trouble brewing? Am J Obstet Gynecol 140:607–610
Parsons WD, Neims AH (1981) Prolonged half-life of caffeine in healthy newborn infants. J Pediatr 93:640–641
Parsons WD, Aranda JV, Neims AH (1976) Elimination of transplacentally acquired caffeine in full-term neonates. Pediatr Res 10:333
Sameroff A (1978) Organization and stability of newborn behavior: A commentary on the Brazelton Neonatal Assessment scale. Monogr Soc Res Child Dev 43:(5–6), Serial N. 177
Soule AB, Stanley K, Copans S, Davis M (1974) Clinical uses of the Brazelton Neonatal Scale. Pediatrics 54:583–586
Soyka LF (1981 a) Introduction. Semin Perinatol 5:303–304
Soyka LF (1981 b) Caffeine ingestion during pregnancy: In utero exposure and possible effects. Semin Perinatol 5:305–309
Soyka LF, Neese AL, Main D, Main E (1981) Studies of caffeine and theophylline in the neonate. Semin Perinatol 5:332–336
Weathersbee PS, Lodge JR (1977) Caffeine: Its direct and indirect influence on reproduction. J Reprod Med 19:55–63
Author information
Authors and Affiliations
Additional information
This research was supported by National Science Foundation Grant # RII8400048 and BNS-8696151 and Biomedical Research Support Grant # S07RR07149-10 awarded to the senior author
Rights and permissions
About this article
Cite this article
Emory, E.K., Konopka, S., Hronsky, S. et al. Salivary caffeine and neonatal behavior: assay modification and functional significance. Psychopharmacology 94, 64–68 (1988). https://doi.org/10.1007/BF00735882
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00735882