Psychopharmacology

, Volume 94, Issue 1, pp 21–23 | Cite as

Improved recognition memory in monkeys following naloxone administration

  • T. G. Aigner
  • M. Mishkin
Original Investigations

Abstract

The effects of naloxone on visual recognition were evaluated in five macaques trained in delayed nonmatching-to-sample with trial-unique objects. In four of the five monkeys, naloxone yielded an inverted U-shaped dose-effect curve. For each of these four animals, as well as for all five animals as a group, at least one dose within a narrow range (0.32–3.2 mg/kg) produced a significant increase in the number of objects correctly recognized. Lower doses had little effect, while the highest dose (10.0 mg/kg) tended to disrupt performance.

Key words

Memory Naloxone Monkeys 

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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • T. G. Aigner
    • 1
  • M. Mishkin
    • 1
  1. 1.Laboratory of Neuropsychology, Building 9, Room 1N107National Institute of Mental HealthBethesdaUSA

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