Psychopharmacology

, Volume 47, Issue 2, pp 205–208 | Cite as

Effects of low and moderate doses of chlorpromazine on discrimination learning in the rat

  • John I. Telner
  • Vaira Vikis-Freibergs
  • Franco Lepore
Animal Studies

Abstract

The effects of chlorpromazine on the acquisition of a brightness discrimination with food reward were examined. Doses of 0.5, 1.0 or 2.0 mg/kg of CPZ as well as saline were administered intraperitoneally to 4 groups of 7 Sprague-Dawley rats, 1 h prior to testing. After a 3-week period of habituation and pre-training, rats were tested 20 trials a day, 7 days a week. No drug effect was found on the number of trials to reach a criterion of 18/20 successive correct responses, which required an average of 6.2 days of training. Precriterion latencies, however, showed an increase as a function of increasing dose level. Postchoice latencies were not affected, eliminating motor retardation as an explanation for the latency effect.

Key words

Chlorpromazine Appetivive learning Discrimination Discrete trials Latencies 

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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • John I. Telner
    • 1
  • Vaira Vikis-Freibergs
    • 1
  • Franco Lepore
    • 1
  1. 1.Département de PsychologieUniversité de MontréalMontréalCanada

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