Journal of Inherited Metabolic Disease

, Volume 17, Issue 1, pp 89–92 | Cite as

Mucopolysaccharidosis type II (Hunter syndrome): Characterization of the iduronate-2-sulphatase in MPS II skin fibroblasts

  • L. Petruschka
  • M. Zschiesche
  • J. Bielicki
  • G. Seidlitz
  • G. Machill
  • J. J. Hopwood
  • F. H. Herrmann
Article

Summary

Iduronate-2-sulphatase was characterized kinetically in MPS II fibroblasts.

Keywords

Public Health Internal Medicine Skin Fibroblast Mucopolysaccharidosis Hunter Syndrome 

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References

  1. Bielicki J, Freeman C, Clements PR, Hopwood JJ (1990) Human liver iduronate-2-sulphatase. Purification, characterization and catalytic properties.Biochem J 271: 75–86.Google Scholar
  2. Brooks DA, McCourt PAG, Gibson GJ, Ashton LJ, Shutter M, Hopwood JJ (1991) Analysis ofN-acetylgalactosamine-4-sulphatase protein and kinetics in mucopolysaccharidosis type VI patients.Am J Hum Genet 48: 710–719.Google Scholar
  3. Di Natale P, Daniele A (1981) Iduronate sulphatase from human placenta.Biochim Biophys Acta 661: 106–111.Google Scholar
  4. Wehnert M, Hopwood JJ, Schröder W, Herrmann FH (1992) Structural gene aberrations in mucopolysaccharidosis II (Hunter).Hum Genet 89: 430–432.Google Scholar

Copyright information

© SSIEM and Kluwer Academic Publishers 1994

Authors and Affiliations

  • L. Petruschka
    • 1
  • M. Zschiesche
    • 1
  • J. Bielicki
    • 2
  • G. Seidlitz
    • 1
  • G. Machill
    • 1
  • J. J. Hopwood
    • 2
  • F. H. Herrmann
    • 1
  1. 1.Institute of Medical GeneticsErnst-Moritz-Arndt UniversityGreifswaldGermany
  2. 2.Department of Chemical PathologyAdelaide Children's HospitalNorth AdelaideAustralia

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