Summary
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1.
Several weeks after administration of 5,7-dihydroxytryptamine (5,7-DHT) toAplysia, a dark pigmentation appears in serotonin-containing neurons, and this pigmentation allows visual identification of serotonergic neurons but does not appear to alter their physiology.
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2.
We have determined the distribution of labeled nerve cell bodies in the various ganglia ofAplysia and have characterized the pigment containing structures in both control and labeled neurons.
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3.
All neurons in this preparation, whether or not they utilize serotonin as a transmitter, contain pigment granules, and three types of pigment granules can be distinguished. After 5,7-DHT a new type of granule appears in serotonergic neurons, probably reflecting lysosomes that have accumulated serotonergic synaptic vesicles that contain the oxidized 5,7-DHT.
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4.
It remains unclear why this substance does not cause neurotoxicity in mollusks as it does in mammalian preparations.
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Hernádi, L., S.-Rózsa, K., Jahan-Parwar, B. et al. A topography and ultrastructural characterization ofin vivo 5,7-dihydroxytryptamine-labeled serotonin-containing neurons in the central nervous system ofAplysia californica . Cell Mol Neurobiol 12, 317–326 (1992). https://doi.org/10.1007/BF00734932
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DOI: https://doi.org/10.1007/BF00734932