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Hypothalamic polar spongioblastoma associated with the diencephalic syndrome

Ultrastructural demonstration of a neuro-endocrine organization

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Summary

A tumor was resected from the third ventricle of a four years and eleven month old girl with the diencephalic syndrome. By light microscopy, it was diagnosed as a polar spongioblastoma.

Its ultrastructural study was undertaken and the features were found to be distinctive and previously unreported. The organization of the neoplasm was similar to that of the hypothalamic neuro-endocrine systems: Cellular perivascular arrangement with intra-cytoplasmic microtubules and membrane bound dense-core granules.

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Author information

Author notes

  1. Robert D. Hollenberg

    Present address: McMaster University Medical Center, Hamilton, Ontario, Canada

Authors and Affiliations

  1. Department of Pathology, Montreal Children's Hospital and McGill University, Montreal Children's Hospital Research Institute, 2300 Tupper Street, H3H IP3, Montreal, Quebec, Canada

    Jean-Pierre de Chadarévian

  2. Department of Endocrinology, Montreal Children's Hospital and McGill University, Montreal Children's Hospital Research Institute, 2300 Tupper Street, H3H IP3, Montreal, Quebec, Canada

    Harvey J. Guyda

  3. Department of Neuro-Surgery, Montreal Children's Hospital and McGill University, Montreal Children's Hospital Research Institute, 2300 Tupper Street, H3H IP3, Montreal, Quebec, Canada

    Robert D. Hollenberg

Authors
  1. Jean-Pierre de Chadarévian
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  2. Harvey J. Guyda
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  3. Robert D. Hollenberg
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de Chadarévian, JP., Guyda, H.J. & Hollenberg, R.D. Hypothalamic polar spongioblastoma associated with the diencephalic syndrome. Vichows Archiv A Pathol Anat 402, 465–474 (1984). https://doi.org/10.1007/BF00734643

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  • DOI: https://doi.org/10.1007/BF00734643

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