Summary
A cerebral neoplasm containing a well differentiated epidermoid cyst surrounded by islands of infiltrating squamous cell carcinoma and a pleomorphic spindle cell stroma was described. By immunoperoxidase staining all these components contained keratin. The lesion was therefore similar to malignant squamous cell lesions with sarcoma-like stroma occurring in other body sites.
Similar content being viewed by others
References
Battifora H (1976) Spindle cell carcinoma. Cancer 37:2275–2282
Burger PC, Vogel FS (1982) Surgical pathology of the nervous system and its covering (2nd ed). J Wiley and Sons New York, pp 375–378
Du Boulay CEH, Isaacson P (1981) Carcinoma of the oesophagus with spindle cell features. Histopathology 5:403–414
Enrile FT, de Jesus PO, Bakst AA, Baluyot R (1973) Pseudosarcoma of the esophagus (polipoid carcinoma of esophagus with pseudosarcomatous features). Cancer 31:1197–1202
Espinoza CC, Azar HA (1982) Immunohistochemical localization of keratin-type proteins in epithelial neoplasms. Am J Clin Pathol 78:500–507
Gabbiani G, Kapanci Y, Barazzone P, Franke WW (1981) Immunochemical identification of intermediate-sized filaments in human neoplastic cells. A diagnostic aid for the surgical pathologist. Am J Pathol 104:206–216
Garcia CA, McGarry PA, Rodriguez F (1981) Primary intracranial squamous cell carcinoma of the right cerebellopontine angle. J Neurosurg 54:824–828
Giangaspero F, Baruzzi G, Lemma E, Lorenzini P, Minghetti G, Ferracini R (1978) Carcinomi fusocellulari del laringe. Pathologica 70:537–545
Goellner JR, Devine KD, Weiland LH (1973) Pseudosarcoma of the larynx. Am J Clin Pathol 59:312–326
Kernohan JW, Uihlein A (1962) Sarcomas of the Brain. CC Thomas, Springfield, pp 25–69
Leifer C, Miller AS, Putong PB, Min BH (1974) Spindle-cell carcinoma of the oral mucosa. A light and electron microscopic study of apparent sarcomatous metastases to cervical lymph nodes. Cancer 34:597–605
Miettinen M, Lheto VP, Virtanen I (1982) Keratin in the epithelial-like cells of classical bifasic synovial sarcoma. Virchows Arch [Cell Pathol] 40:157–161
Minkler DS, Meligro CH, Norris HT (1970) Carcinosarcoma of the larynx. Case report with metastases of epidermoid and sarcomatous elements. Cancer 26:195–200
Osamura RY, Shimamura K, Hata J, Tomaoki N, Watanabe K, Kubota M, Yamazaki S, Mitomi T (1978) Polipoid carcinoma of esophagus. A unifying term for “carcinosarcoma” and “pseudosarcoma”. Am J Surg Pathol 2:201–208
Piscioli F, Aldovini D, Bondi A, Eusebi V (1984) Squamous cell carcinoma with sarcoma-like stroma of the paranasal sinuses. Histopathology (in press)
Rojas-Espinosa O, Dannenberg AM, Sternberger LA, Tsuda T (1974) The role of cathepsin D in the pathogenesis of tubercolosis. Am J Pathol 74:1–18
Steeper TA, Piscioli F, Rosai J (1983) Squamous cell carcinoma with sarcoma-like stroma of the female genital tract. Cancer 52:890–898
Stener B, Kock NG, Petterson S, Zetterlund B (1967) Carcinosarcoma of the esophagus. J Thorac Cardiovasc Surg 54:746–750
Sienski W, Dorsett B, Ioachim HL (1981) Identification of prekeratin by immunofluorescence staining in the differential diagnosis of tumors. Hum Pathol 12:452–458
Stromeyer F (1909) Ober ein mit Sarkom kombiniertes Cholesteatom des Gehirns. Beitr Pathol Anat Pathol 47:392–398
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Giangaspero, F., Manetto, V., Ferracini, R. et al. Squamous cell carcinoma of the brain with sarcoma-like stroma. Vichows Archiv A Pathol Anat 402, 459–464 (1984). https://doi.org/10.1007/BF00734642
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00734642