Virchows Archiv A

, Volume 414, Issue 4, pp 321–324 | Cite as

Electron microscopic studies of endocrine hyperplasia in duodenal adenomas in familial adenomatous polyposis

  • Anne Mellon Mogensen
  • Esther Hage
  • Steffen Bülow


Electron microscopical studies on endocrine cell hyperplasia of duodenal adenomas from five patients with familial adenomatous polyposis were performed. All the endocrine cell types normally found in the duodenal mucosa were identified. A constant feature was proliferation of duodenal-enterochromaffin cells but an increase in the number of all other endocrine cell types apart from pyloricgastrin cells and somatostatin cells, was also observed. Certain types of intestinal endocrine cells (the intestinal enterochromaffin cell and the glicentin cell) are rare cells in the normal duodenal mucosa. The finding of these cells may indicate increased biological aggressivity.

Key words

Familial adenomatous polyposis Duodenal adenomas Endocrine hyperplasia Electron microscopical studies 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Bülow S (1986) Familial polyposis coli. A clinical and epidemiological study. Thesis, Lægeforeningens Forlag, CopenhagenGoogle Scholar
  2. Gould VE, Yannopoulos AD, Sommers SC, Terzakis JA (1978) Neuroendocrine cells in dysplastic bronchi. Ultrastructural observations and quantitative analysis of secretory granules and the Golgi complex. Am J Pathol 90:49–54Google Scholar
  3. Hage E (1976) Endocrine cells in the metaplastic epithelia. In: Fujita (ed) Endocrine gut an pancreas. Elsevier, Amsterdam, pp 365–369Google Scholar
  4. Holmes EJ (1966) Morphogenesis of gastric adenomatous polyps. Transformation to invasive carcinoma of intestinal type. Cancer 19:794–802Google Scholar
  5. Karnovsky MJ (1965) A formaldehyde-glutaraldehyde fixative of high osmolality for use in electronmicroscopy (Abstr.). J Cell Biol 27:137AGoogle Scholar
  6. Mogensen AM, Bülow S, Hage E (1988) Duodenal adenomas in familial adenomatous polyposis: their structure and cellular composition with particular reference to endocrine hyperplasia.Google Scholar
  7. Monnier P, Fontolliet C, Savary M, Ollyo J-B (1988) Barrett's esophagus or columnar epithelium of the lower esophagus. In: Boesby S, Sørensen HR (eds) Esophagus -88. The present status of diagnosis and treatment of esophageal diseases. Interprint A/S, Copenhagen, pp 127–134Google Scholar
  8. Morson BC (1955) Gastric polyps composed of intestinal epithelium. Brit J Cancer 9:550–557Google Scholar
  9. Polak JM, Bloom SR (1987) Some aspects of neuroendocrine pathology. J Clin Pathol 40:1024–1041Google Scholar
  10. Solcia E, Polak JM, Buffa R, Capella C, Pearse AGE (1975) Endocrine cells of the intestinal mucosa. In: Thompson JC (ed) Symposium. Gastrointestinal hormones. University of Texas Press, Austin and London, pp 155–168Google Scholar
  11. Solcia E, Capella C, Buffa R, Frigeria B (1976) Histochemical and ultrastructural studies on the argentaffin and argyrophil cell of the gut. In: Coupland RE, Fujita T (eds) Chromaffin, enterochromaffin and related cells. Elsevier, Amsterdam, pp 209–225Google Scholar
  12. Solcia E, Polak JM, Larsson L-I, Buchan AMJ, Capella C (1981) Update on Lausanne classification of endocrine cells. In: Bloom SR, Polak JM (eds) Gut hormones, 2nd edn, Churchill Livingstone, Edinburgh, pp 96–100Google Scholar
  13. Usellini L, Capella C, Solcia E, Buchan AMJ, Brown JC (1984a) Ultrastructural localization of gastric inhibitory polypeptide (GIP) in a well characterized endocrine cell of canine duodenal mucosa. Histochemistry 80:85–89Google Scholar
  14. Usellini L, Capella C, Frigerio B, Rindi G, Solcia E (1984b) Ultrastructural localization of secretion in endocrine cells of the dog duodenum by the immunogold technique. Comparison with ultrastructurally characterized S cells of various mammals. Histochemistry 80:435–441Google Scholar
  15. Usellini L, Buchan AMJ, Polak JM, Capella C, Cornaggia M, Solcia E (1984c) Ultrastructural localization of motilin in endocrine cells of human and dog intestine by the immunogold technique. Histochemistry 81:363–368Google Scholar
  16. Usellini L, Capella C, Malesci A, Rindi G, Solcia E (1985) Ultrastructural localization of cholecystokinin in endocrine cells of the dog duodenum by the immunogold technique. Histochemistry 83:331–336Google Scholar
  17. Watanabe H (1972) Argentaffin cells in adenoma of the stomach. Cancer 30:1267–1274Google Scholar

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • Anne Mellon Mogensen
    • 1
  • Esther Hage
    • 1
  • Steffen Bülow
    • 1
  1. 1.Department of Pathology and Department of Surgical Gastroenterology C, RigshospitaletUniversity of CopenhagenCopenhagen ØDenmark

Personalised recommendations