Cellular and Molecular Neurobiology

, Volume 4, Issue 4, pp 397–402 | Cite as

Estradiol increases dopamine turnover in intermediate and posterior pituitary lobes of ovariectomized rats

  • Juan M. Saavedra
  • Claude Chevillard
  • Jean Claude Bisserbe
  • Nicholas Barden
Short Communication


  1. 1.

    Dopamine levels were specifically increased in the intermediate lobe of the pituitary gland of ovariectomized rats following acute 17-β-estradiol administration.

  2. 2.

    Estradiol treatment increased the dopamine turnover rate 10-fold in the intermediate lobe and 2-fold in the posterior lobe of ovariectomized rats.

  3. 3.

    In contrast, estrogen treatment had no effect on the endogenous levels or the turnover rate of norepinephrine in these tissues.

  4. 4.

    Our results suggest that estrogens can selectively modulate dopamine metabolism in the posterior and intermediate lobes of the rat pituitary gland.


Key words

estradiol dopamine turnover norepinephrine posterior pituitary lobe intermediate pituitary lobe rat 


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Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • Juan M. Saavedra
    • 1
  • Claude Chevillard
    • 1
  • Jean Claude Bisserbe
    • 1
  • Nicholas Barden
    • 1
  1. 1.Laboratory of Clinical Science, Section on PsychopharmacologyNational Institute of Mental HealthBethesdaUSA

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