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A novel method for glycoconjugate synthesis

  • Glycoconjugate Journal
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Abstract

2-Chloroethyl 1-thio-β-d-galactopyranoside and the corresponding 1-thio-β-d-glucopyranoside have been found to be suitable glycosylating agents for the preparation of different types of glycoconjugates. Glycosylation of bovine serum albumin and chymotrypsin were chosen as examples of an application of the described compounds. The glycosylating agents can modify not only amino groups, but also alkyl hydroxyl and aryl hydroxyl groups, as was shown in experiments with model water soluble and water insoluble polyacrylamide copolymers.

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Authors and Affiliations

  1. Department of Biochemistry, Charles University, Albertov 2030, 128 40, Praha 2, Czech Republic

    M. Tichá

  2. Department of Organic Chemistry, Charles University, Albertov 2030, 128 40, Praha 2, Czech Republic

    M. Černý & T. Trnka

Authors
  1. M. Tichá
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  2. M. Černý
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  3. T. Trnka
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Tichá, M., Černý, M. & Trnka, T. A novel method for glycoconjugate synthesis. Glycoconjugate J 13, 681–685 (1996). https://doi.org/10.1007/BF00731457

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  • DOI: https://doi.org/10.1007/BF00731457

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