Glycoconjugate Journal

, Volume 12, Issue 5, pp 729–731 | Cite as

The anti-oligosaccharide antibodies present in sera from patients with motor neuron disease and neuropathy recognize theN-glycolylneuraminic acid containing gangliotetrahexosyl oligosaccharide

  • Marinella Carpo
  • Eduardo Nobile-Orazio
  • Vanna Chigorno
  • Sandro Sonnino
Glycoconjugate Papers

Abstract

We found that serum antibodies present in the serum of patients with motor neuron disease and neuropathy, which were previously shown to react with the oligosaccharide chain of ganglioside GM1(Neu5Ac), can be recognized and titred using theN-glycolylneuraminic acid containing monosialo-gangliotetrahexosylceramide, GM1(Neu5Gc), which is not a component of normal human cells. The antibody-antigen reaction was abolished by immunoabsorption with the free oligosaccharide chain. This result, together with the knowledge that these antibodies recognize several glycoconjugates, supports the conviction that these antibodies are non-specific for a gangliosidic structure.

Keywords

membrane glycoconjugates neuropathy antibodies 

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Copyright information

© Chapman & Hall 1995

Authors and Affiliations

  • Marinella Carpo
    • 1
  • Eduardo Nobile-Orazio
    • 1
  • Vanna Chigorno
    • 2
  • Sandro Sonnino
    • 2
  1. 1.Institute of Clinical Neurology, Centro Dino FerrariItaly
  2. 2.Study Center for the Functional Biochemistry of Brain Lipids, Department of Medical Chemistry and BiochemistryUniversity of MilanMilanItaly

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