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Isolation and characterization of a pseudogene related to human core 2 β-1,6-N-acetylglucosaminyltransferase

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Abstract

In a previous study, we isolated genomic clones encoding core 2β-1,6-N-acetylglucosaminyltransferase (C2GnT) and blood group IGnT and proposed that these two genes were produced from a common ancestral gene by duplication, diversion and intron insertion. In the present study, we have isolated a pseudogene which is highly related to the gene ofC2GnT. The sequence analysis of this pseudogene indicated that the pseudogene was produced by duplication of a common precursor gene forC2GnT. These results taken together strongly suggest that the ancestral gene was first duplicated and one of the duplicated genes directly evolved into theIGnT gene. The other duplicated gene was further duplicated to produce theC2GnT gene and the pseudogene.

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Author notes

  1. Marti F. A. Bierhuizen

    Present address: Department of Hematology, Erasmus University, Rotterdam, The Netherlands

  2. Kentaro Maemura

    Present address: Department of Internal Medicine, Osaka Medical College, Takatsuki, Japan

Authors and Affiliations

  1. Glycobiology Program, La Jolla Cancer Research Foundation, 92037, La Jolla, California, USA

    Marti F. A. Bierhuizen, Kentaro Maemura & Minoru Fukuda

Authors
  1. Marti F. A. Bierhuizen
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  2. Kentaro Maemura
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  3. Minoru Fukuda
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Bierhuizen, M.F.A., Maemura, K. & Fukuda, M. Isolation and characterization of a pseudogene related to human core 2 β-1,6-N-acetylglucosaminyltransferase. Glycoconjugate J 12, 857–864 (1995). https://doi.org/10.1007/BF00731248

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  • DOI: https://doi.org/10.1007/BF00731248

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