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Chronic relapsing polyradiculoneuritis in a dog a clinical, light- and electron-microscopic study

Summary

A 6-year-old dog was afflicted with a paresis that developed insidiously and abated during a temporary remission. Clinical findings included: tetraparesis, diminished or absent reflexes, muscle wasting, albuminocytologic dissociation, muscle denervation potentials, and delayed peripheral nerve conduction velocities. The pathologic changes were those of a longstanding demyelinating polyradiculoneuritis. Segmental myelin breakdown, which occurred in the presence of invading cells, and apparently in their absence, was accompanied by some Wallerian degeneration. Reparative changes were noted in numerous small onion bulb formations. Myelin was restored to demyelinated axon segments in the cores of the onion bulbs, while axon sprouts appeared in the peripheral Schwann cell lamellae. This polyradiculoneuritis was unlike spontaneous canine neuritides previously reported, and was compared with experimentally induced peripheral nerve disorders and spontaneous poly-neuritides in man.

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Cummings, J.F., de Lahunta, A. Chronic relapsing polyradiculoneuritis in a dog a clinical, light- and electron-microscopic study. Acta Neuropathol 28, 191–204 (1974). https://doi.org/10.1007/BF00719024

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  • DOI: https://doi.org/10.1007/BF00719024

Key words

  • Comparative Neuropathology
  • Canine Polyneuritis
  • Demyelination
  • Onion Bulb Formation