Summary
A 6-year-old dog was afflicted with a paresis that developed insidiously and abated during a temporary remission. Clinical findings included: tetraparesis, diminished or absent reflexes, muscle wasting, albuminocytologic dissociation, muscle denervation potentials, and delayed peripheral nerve conduction velocities. The pathologic changes were those of a longstanding demyelinating polyradiculoneuritis. Segmental myelin breakdown, which occurred in the presence of invading cells, and apparently in their absence, was accompanied by some Wallerian degeneration. Reparative changes were noted in numerous small onion bulb formations. Myelin was restored to demyelinated axon segments in the cores of the onion bulbs, while axon sprouts appeared in the peripheral Schwann cell lamellae. This polyradiculoneuritis was unlike spontaneous canine neuritides previously reported, and was compared with experimentally induced peripheral nerve disorders and spontaneous poly-neuritides in man.
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Ballin, R. H. M., Thomas, P. K.: Electron microscope observations on demyelination and remyelination in experimental allergic neuritis. Part I. Demyelination. J. neurol. Sci.8, 1–18 (1969)
Carpenter, S.: An ultrastructural study of an acute fatal case of the Guillain-Barré syndrome. J. neurol. Sci.15, 125–140 (1972)
Cummings, J. F., Haas, D. C.: Coonhound paralysis: An acute idiopathic polyradiculoneuritis in dogs resembling the Landry-Guillain-Barré syndrome. J. neurol. Sci.4, 51–81 (1967)
Cummings, J. F., Lorenz, M. D., de Lahunta, A., Washington, L. D.: Canine brachial plexus neuritis: A syndrome resembling serum neuritis in man. Cornell Vet.63, 589–617 (1973)
Dalton, A. J.: A chrome-osmium fixative for electron microscopy. Anat. Rec.121, 281 (1955)
de Lahunta, A.: Small animal neurologic examination. Vet. clin. N. Amer.1, 191–206 (1971)
Dyck, P. J.: Experimental hypertrophic neuropathy. Arch. Neurol. (Chic.)21, 73–95 (1969)
Dyck, P. J., Gomez, M. R.: Segmental demyelination in Dejerine-Sottas disease. Proc. Mayo Clin.43, 280–295 (1968)
Hart, M. N., Hanks, D. T., Mackey, R.: Ultrastructural observations in Guillain-Barré syndrome. Arch. Path.93, 552–555 (1972)
Hirano, A., Cook, S. D., Whitaker, J. N., Dowling, P. C., Murray, M. R.: Fine strucrural aspects of demyelinationin vitro. The effects of Guillain-Barré serum. J. Neuropath. exp. Neurol.30, 249–265 (1971)
Lampert, P. V.: Mechanism of demyelination in experimental allergic neuritis. Electron microscopic studies. Lab. Invest.20, 127–138 (1969)
Lampert, P. W., Schochet, S. S.: Demyelination and remyelination in lead neuropathy. J. Neuropath. exp. Neurol.27, 527–545 (1968)
Lee, A. F., Bowen, J. M.: Evaluation of motor nerve conduction velocity in the dog. Amer. J. vet. Res.31, 1361–1366 (1970)
Nathaniel, E. J. H., Pease, D. C.: Regenerative changes in rat dorsal roots following Wallerian degeneration. J. Ultrastruct. Res.9, 533–549 (1963)
Ochoa, J., Fowler, T. G., Gilliott, R. N.: Anatomical changes in peripheral nerves compressed by a pneumatic tourniquet. J. Anat. (Lond.)133, 433–455 (1972)
Pleasure, D. E., Towfighi, J.: Onion bulb neuropathies. Arch. Neurol. (Chic.)26, 289–301 (1972)
Prineas, J.: Polyneuropathies of undetermined cause. Acta neurol. scand., Suppl.46, 1–72 (1970)
Prineas, J. W.: Demyelination and remyelination in recurrent idiopathic polyneuropathy. An electron microscopy study. Acta neuropath. (Berl.)18, 34–57 (1971)
Prineas, J. W.: Acute idiopathic polyneuritis. An electron microscope study. Lab. Invest.26, 133–147 (1972)
Raine, C. S., Wiśniewski, H., Prineas, J.: An ultrastructural study of experimental demyelination and remyelination. II. Chronic experimental allergic encephalomyelitis in the peripheral nervous system. Lab. Invest.21, 316–327 (1969)
Sandbank, U., Bechar, M., Bornstein, B.: Hyperlipemic neuropathy. Case report: Histological and electron-microscopical study. Acta neuropath. (Berl.)19, 290–300 (1971)
Satinsky, D., Pepe, F. A., Liu, C. N.: The neurilemma cell in peripheral nerve degeneration and regeneration. Exp. Neurol.9, 441–451 (1964)
Thomas, P. K., Lascelles, R. G.: Hypertrophic neuropathy. Quart. J. Med.36, 223–238 (1967)
Tomonaga, M., Sluga, E.: Zur Ultrastruktur der π Granula. Acta neuropath. (Berl.)15, 56–69 (1970)
Venable, J. H., Coggeshall, R.: A simplified lead citrate strain for use in electron microscopy. J. Cell Biol.25, 407–408 (1965)
Webster, H. F., de Schröder, J. M., Asbury, A. K., Adams, R. D.: The role of Schwann cells in the formation of “onion bulbs” found in chronic neuropathies. J. Neuropath. exp. Neurol.26, 276–299 (1967)
Whitaker, J. N., Hirano, A., Cook, S. D., Dowling, P. C.: The ultrastructure of circulating immunocytes in Guillain-Barré syndrome. Neurology (Minneap.)20, 765–770 (1970)
Wiśniewski, H., Prineas, J., Raine, C. S.: An ultrastructural study of experimental demyelination and remyelination. I. Acute experimental allergic encephalomyelitis in the peripheral nervous system. Lab. Invest.21, 105–118 (1969a)
Wiśniewski, H., Terry, R. D., Whitaker, J. N., Cook, S. D., Dowling, P. C.: Landry-Guillain-Barré syndrome—a primary demyelinating disease. Arch. Neurol. (Chic.)21, 269–276 (1969b)
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Cummings, J.F., de Lahunta, A. Chronic relapsing polyradiculoneuritis in a dog a clinical, light- and electron-microscopic study. Acta Neuropathol 28, 191–204 (1974). https://doi.org/10.1007/BF00719024
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DOI: https://doi.org/10.1007/BF00719024