Virchows Archiv A

, Volume 415, Issue 6, pp 539–544 | Cite as

Immunocytochemical reactivity of breast cancer tissue with antibodies to neuron-specific enolase and an adenocarcinoma-associated glycolipid antigen

  • H. Ingelman-Sundberg
  • B. Wikström
  • N. Stormby
  • P. Sundelin
  • A. Hjerpe


The immunocytochemical reactivity of breast cancers to antibodies raised against neuron-specific enolase (NSE), carcinoembryonic antigen (CEA) and an adenocarcinoma-associated glycolipid antigen (IR-14) was studied in relation to the long-term outcome of the neoplastic disease.

The patients whose tumours exhibited reactivity with the IR-14 and anti-NSE antibodies had a considerably better 5-year and long-term survival than those without such reactivity. Assessment of DNA-ploidy of the tumour cells was also relevant for long-term prognosis, immunohistochemistry giving additional prognostic information among aneuploid tumours. Reactivity with polyclonal CEA antibodies was of no prognostic value.

It is suggested that tumors carrying the IR-14 reactive epitope, which was originally isolated from circulating antigen-antibody complexes, might evoke a favourable immune response and thus improve the survival of the patient.

Key words

Breast cancer tumor markers Immunohistochemistry Glycolipid antigen Neuron-specific enolase 


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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • H. Ingelman-Sundberg
    • 1
  • B. Wikström
    • 1
  • N. Stormby
    • 2
  • P. Sundelin
    • 3
  • A. Hjerpe
    • 1
  1. 1.Department of Pathology II, Karolinska InstituteF-42 Huddinge University HospitalHuddingeSweden
  2. 2.Department of Clinical CytologyMalmö General HospitalMalmöSweden
  3. 3.Department of PathologySödersjukhuset, StockholmSweden

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