Skip to main content
SpringerLink
Log in

Malignant lymphomas of the nasal cavity and paranasal sinuses

  • Published:
Virchows Archiv A Aims and scope Submit manuscript

Summary

The incidence of malignant lymphomas in the nasal cavity and paranasal sinuses was found tobe 0.17% of all malignant lymphomas and 0.44% of all extranodal malignant lymphomas registered in the Kiel Lymph Node Registry from 1972 to 1987. Fifty-nine cases of malignant lymphoma presenting in the nasal cavity and paranasal sinuses were investigated with morphological and immunological methods. The median age of the patients was 64.5 years, with a female predominance (m:f=0.87:1). In the 59 cases a marked preponderance of B-cell lymphomas was found (centroblasticn=15, immunoblasticn=8, Burkitt's lymphoman=6, Immunocytoman=3, centrocyticn=1, centroblastic/centrocyticn=1, plasmacyticn=11); only a small number (n=5) was of T-cell lineage (pleomorphic types). Nine further cases could not be assigned with certainty to either the T or B cell system. Angiocentricity with infiltration and destruction of vessel walls by tumour cells was demonstrated only in the T-cell lymphomas; the B-cell lymphomas, in contrast, of ten surrounded and compressed blood vessels with intact endothelium. No similarity to malignant lymphomas of mucosa associated lymphoid tissue, such as those in the gastrointestinal tract, was detected.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Addis BJ, Hyjek E, Isaacson PG (1988) Primary pulmonary lymphoma: a re-appraisal of its histogenesis and its relationship to pseudolymphoma and lymphoid interstitial pneumonia. Histopathology 13:1–17

    Google Scholar 

  • Chan JKC, Ng CS, Lau WH, Lo STH (1987) Most nasal/ nasopharyngeal lymphomas are peripheral T-cell lymphomas. Am J Surg Pathol 11(6):418–429

    Google Scholar 

  • Chott A, Rappersberger K, Schlossareck W, Radaszkiewicz T (1988) Peripheral T cell lymphoma presenting primarily as lethal midline granuloma. Hum Pathol 19:1093–1101

    Google Scholar 

  • Crissman JD (1979) Midline malignant reticulosis and lymphomatoid granulomatosis. A case report. Arch Pathol Lab Med 103:561–564

    Google Scholar 

  • Crissman JD, Weiss MA, Gluckman J (1982) Midline granuloma syndrome. A clinicopathological study of 13 patients. Am J Surg Pathol 6:335–346

    Google Scholar 

  • Editorial (1977) Non-healing (midline) granuloma. Lancet i:1926–1927

    Google Scholar 

  • Eichel BS, Harrison EG, Devine KD, Scanlon PW, Brown HA (1966) Primary lymphoma of the nose including a relationship to lethal midline granuloma. Am J Surg 112:597–605

    Google Scholar 

  • Feller AC, Wacker HH, Moldenauer G, Radzun HJ, Parwaresch MR (1987) Monoclonal antibody Ki-B3 detects a formalin resistant antigen on normal and neoplastic B-cells. Blood 70:629–636

    Google Scholar 

  • Freeman C, Berg JW, Cutler SJ (1972) Occurrence and prognosis of extranodal lymphomas. Cancer 29:252–260

    Google Scholar 

  • Frierson HF, Mills SE, Innes DJ (1984) Non-Hodgkin's lymphomas of the sinonasal region: Histologic subtypes and their clinicopathologic features. Am J Clin Pathol 81:721–727

    Google Scholar 

  • Fu YS, Perzin KH (1978) Nonepithelial tumors of the nasal cavity, paranasal sinuses and nasopharynx. A clincopathologic study. IX. Plasmacytomas. Cancer 42:2399–3406

    Google Scholar 

  • Fu YS, Perzin KH (1979) Nonepithelial tumors of the nasal cavity, paranasal sinuses and neopharynx. A clincopathologic study. X. Malignant lymphomas. Cancer 43:611–621

    Google Scholar 

  • Gall EA, Mallory TB (1942) Malignant lymphoma. A clinicopathologic survey of 618 cases. Am J Pathol 18:381–429

    Google Scholar 

  • Gatter KC, Mason DY, Hyderman E, Isaacson PG (1987) Commentary: Which antibodies for diagnostic pathology? Histopathology 11:661–664

    Google Scholar 

  • Hansmann M-L, Wacker HH, Radzun HJ (1981) Paragranuloma is a variant of Hodgkin's disease with predominance of B cells. Virchows Arch [A] 409:171–181

    Google Scholar 

  • Hsu SM, Raine L, Fanger H (1981) The use of antiavidin antibody and avidin-biotin-peroxidase complex in immunoperoxidase technics. Am J Clin Pathol 75:816–821

    Google Scholar 

  • Hui PK, Feller AC, Lennert K (1988) High-grade non-Hodgkin's lymphoma of B-cell type. I. Histopathology 12:127–143

    Google Scholar 

  • Hyjek S, Smith WJ, Isaacson PG (1988) Primary B-cell lymphoma of salivary glands and its relationship to myoepithelial sialadenitis. Hum Pathol 19:766–776

    Google Scholar 

  • Isaacson PG, Spencer J (1987) Malignant lymphoma of mucosa-associated lymphoid tissue. Histopathology 11:445–462

    Google Scholar 

  • Ishii YI, Yamanaka N, Ogawa K, Yoshida Y, Takami T, Matsuura A, Isago H, Kataura A, Kikuchi K (1982) Nasal T-cell lymphoma as a type of so-called “lethal midline granuloma.” Cancer 50:2336–2344

    Google Scholar 

  • Jaffe E (1984) The pathologic and clinical spectrum of postthymic T-cell malignancies. Cancer Invest 2:413–426

    Google Scholar 

  • Kapadia SB, Desai U, Cheng VS (1982) Extramedullary plasmacytoma of the head and neck. A clinicopathologic study of 20 cases. Medicine 61:317–329

    Google Scholar 

  • Li G, Hansmann ML, Lennert K (1988) Morphologie, Immunhistochemie und klinisches Verhalten maligner Lymphome und lymphomähnlicher Läsionen der Lunge. Verh Dtsch Ges Pathol 72:503–504

    Google Scholar 

  • Lippman SM, Grogan TM, Spier CM, Koopman CF, Gall EP, Shimm DS, Durie BGM (1987) Lethal midline granuloma with a novel T-cell phenotype as found in peripheral T-cell lymphoma. Cancer 59:936–939

    Google Scholar 

  • Mason DY, Gatter KC (1987) The role of immunocytochemistry in diagnostic pathology. J Clin Pathol 40:1042–1054

    Google Scholar 

  • Michaels L, Gregory M (1977) Pathology of “non-healing (midline) granuloma”. J Clin Pathol 30:317–327

    Google Scholar 

  • Ng CS, Chan JKC, Cheng PNM, Szeto SC (1986) Nasal T-cell lymphoma associated with hemophagocytic syndrome. Cancer 58:67–71

    Google Scholar 

  • Norton AJ, Ramsay AD, Smith SH, Beverly PCL, Isaacson PG (1980) Monoclonal antibody (UCHL1) that recognizes normal and neoplastic T cells in routinely fixed tissues. J Clin Pathol 39:399–405

    Google Scholar 

  • Poppema S, Hollema H, Visser L, Vos H (1987) Monoclonal antibodies (MT1, MT2, MB1, MB2, MB3) reactive with leukocyte subsets in paraffin embedded tissue sections. Am J Pathol 127(3):418–429

    Google Scholar 

  • Reddy S, Pellettiere E, Saxena V, Hendrickson FR (1980) Extranodal non-Hodgkin's lymphoma. Cancer 46:1925–1931

    Google Scholar 

  • Robbins KT, Fuller LM, Vlasak M, Osborne B, Jing BS, Velasquez WS, Sullivan JA (1985) Primary lymphomas of the nasal cavity and paranasal sinuses. Cancer 56:814–819

    Google Scholar 

  • Sofferman RA, Cummings CW (1975) Malignant lymphoma of the paranasal sinuses. Arch Otolaryngol 101:287–292

    Google Scholar 

  • Stansfeld AG, Diebold J, Kapanci Y, Kelenyi G, Lennert K, Mioduszewska O, Noel H, Rilke F, Sundstrom C, van Unnik J, Wright DH (1988) Updated Kiel classification for lymphoma. Lancet i 292–293, 603

    Google Scholar 

  • Stein H, Gerdes J, Schwab U, Lemke H, Mason DY, Ziegler A, Schienle W, Diehl V (1982) Identification of Hodgkin and Sternberg-Reed cells as a unique cell type derived from a newly detected small cell poputation. Int J Cancer 30:445–459

    Google Scholar 

  • Suchi T, Lennert K, Tu L-Y, Kikuchi M, Sato E, Stansfeld AG, Feller AC (1987) Histopathology and immunohistochemistry of peripheral T cell lymphomas: a proposal for their classification. J Clin Pathol 40:995–1015

    Google Scholar 

  • Wegener F (1939) Über eine eigenartige rhinogene Granulomatose mit besonderer Beteiligung des Arteriensystems und der Nieren. Ziegler's Beitr z pathol Anat 102:36–68

    Google Scholar 

  • West KP, Warford A, Fray L, Allen M (1986) The demonstration of B-cell, T-cell and myeloid antigens in paraffin sections. J Pathol 150:89–101

    Google Scholar 

  • Wilder WH, Harner SG, Banks PM (1983) Lymphoma of the nose and paranasal sinuses. Arch Otolaryngol 109:310–312

    Google Scholar 

  • Wong DS, Fuller LM, Butler JJ, Shullenberger CC (1975) Extranodal non-Hodgkin's lymphomas of the head and neck. Am J Roentgenol, Rad Therapy & Nuclear Med 123:471–481

    Google Scholar 

  • Yamanaka N, Harabuchi Y, Sambe S, Shido F, Matsuda F, Kataura A, Ishii Y, Kikuchi K (1985) Non-Hodgkin's lymphoma of Waldeyer's ring and nasal cavity. Cancer 56:768–776

    Google Scholar 

Download references

Author information

Author notes

  1. Chr Fellbaum

    Present address: Institute of Pathology, University of Graz, Auenbruggerplatz 25, A-8036, Graz, Austria

Authors and Affiliations

  1. Lymph Node Registry, Institute of Pathology, Christian-Albrechts-University, D-2300, Kiel, Germany

    Chr Fellbaum, M. -L. Hansmann & K. Lennert

Authors
  1. Chr Fellbaum
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. -L. Hansmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K. Lennert
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fellbaum, C., Hansmann, M.L. & Lennert, K. Malignant lymphomas of the nasal cavity and paranasal sinuses. Vichows Archiv A Pathol Anat 414, 399–405 (1989). https://doi.org/10.1007/BF00718623

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00718623

Key words

Search

Navigation