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Virchows Archiv A

, Volume 414, Issue 5, pp 399–405 | Cite as

Malignant lymphomas of the nasal cavity and paranasal sinuses

  • Chr Fellbaum
  • M. -L. Hansmann
  • K. Lennert
Article

Summary

The incidence of malignant lymphomas in the nasal cavity and paranasal sinuses was found tobe 0.17% of all malignant lymphomas and 0.44% of all extranodal malignant lymphomas registered in the Kiel Lymph Node Registry from 1972 to 1987. Fifty-nine cases of malignant lymphoma presenting in the nasal cavity and paranasal sinuses were investigated with morphological and immunological methods. The median age of the patients was 64.5 years, with a female predominance (m:f=0.87:1). In the 59 cases a marked preponderance of B-cell lymphomas was found (centroblasticn=15, immunoblasticn=8, Burkitt's lymphoman=6, Immunocytoman=3, centrocyticn=1, centroblastic/centrocyticn=1, plasmacyticn=11); only a small number (n=5) was of T-cell lineage (pleomorphic types). Nine further cases could not be assigned with certainty to either the T or B cell system. Angiocentricity with infiltration and destruction of vessel walls by tumour cells was demonstrated only in the T-cell lymphomas; the B-cell lymphomas, in contrast, of ten surrounded and compressed blood vessels with intact endothelium. No similarity to malignant lymphomas of mucosa associated lymphoid tissue, such as those in the gastrointestinal tract, was detected.

Key words

Malignant lymphoma Nasal cavity Paranasal sinuses 

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References

  1. Addis BJ, Hyjek E, Isaacson PG (1988) Primary pulmonary lymphoma: a re-appraisal of its histogenesis and its relationship to pseudolymphoma and lymphoid interstitial pneumonia. Histopathology 13:1–17Google Scholar
  2. Chan JKC, Ng CS, Lau WH, Lo STH (1987) Most nasal/ nasopharyngeal lymphomas are peripheral T-cell lymphomas. Am J Surg Pathol 11(6):418–429Google Scholar
  3. Chott A, Rappersberger K, Schlossareck W, Radaszkiewicz T (1988) Peripheral T cell lymphoma presenting primarily as lethal midline granuloma. Hum Pathol 19:1093–1101Google Scholar
  4. Crissman JD (1979) Midline malignant reticulosis and lymphomatoid granulomatosis. A case report. Arch Pathol Lab Med 103:561–564Google Scholar
  5. Crissman JD, Weiss MA, Gluckman J (1982) Midline granuloma syndrome. A clinicopathological study of 13 patients. Am J Surg Pathol 6:335–346Google Scholar
  6. Editorial (1977) Non-healing (midline) granuloma. Lancet i:1926–1927Google Scholar
  7. Eichel BS, Harrison EG, Devine KD, Scanlon PW, Brown HA (1966) Primary lymphoma of the nose including a relationship to lethal midline granuloma. Am J Surg 112:597–605Google Scholar
  8. Feller AC, Wacker HH, Moldenauer G, Radzun HJ, Parwaresch MR (1987) Monoclonal antibody Ki-B3 detects a formalin resistant antigen on normal and neoplastic B-cells. Blood 70:629–636Google Scholar
  9. Freeman C, Berg JW, Cutler SJ (1972) Occurrence and prognosis of extranodal lymphomas. Cancer 29:252–260Google Scholar
  10. Frierson HF, Mills SE, Innes DJ (1984) Non-Hodgkin's lymphomas of the sinonasal region: Histologic subtypes and their clinicopathologic features. Am J Clin Pathol 81:721–727Google Scholar
  11. Fu YS, Perzin KH (1978) Nonepithelial tumors of the nasal cavity, paranasal sinuses and nasopharynx. A clincopathologic study. IX. Plasmacytomas. Cancer 42:2399–3406Google Scholar
  12. Fu YS, Perzin KH (1979) Nonepithelial tumors of the nasal cavity, paranasal sinuses and neopharynx. A clincopathologic study. X. Malignant lymphomas. Cancer 43:611–621Google Scholar
  13. Gall EA, Mallory TB (1942) Malignant lymphoma. A clinicopathologic survey of 618 cases. Am J Pathol 18:381–429Google Scholar
  14. Gatter KC, Mason DY, Hyderman E, Isaacson PG (1987) Commentary: Which antibodies for diagnostic pathology? Histopathology 11:661–664Google Scholar
  15. Hansmann M-L, Wacker HH, Radzun HJ (1981) Paragranuloma is a variant of Hodgkin's disease with predominance of B cells. Virchows Arch [A] 409:171–181Google Scholar
  16. Hsu SM, Raine L, Fanger H (1981) The use of antiavidin antibody and avidin-biotin-peroxidase complex in immunoperoxidase technics. Am J Clin Pathol 75:816–821Google Scholar
  17. Hui PK, Feller AC, Lennert K (1988) High-grade non-Hodgkin's lymphoma of B-cell type. I. Histopathology 12:127–143Google Scholar
  18. Hyjek S, Smith WJ, Isaacson PG (1988) Primary B-cell lymphoma of salivary glands and its relationship to myoepithelial sialadenitis. Hum Pathol 19:766–776Google Scholar
  19. Isaacson PG, Spencer J (1987) Malignant lymphoma of mucosa-associated lymphoid tissue. Histopathology 11:445–462Google Scholar
  20. Ishii YI, Yamanaka N, Ogawa K, Yoshida Y, Takami T, Matsuura A, Isago H, Kataura A, Kikuchi K (1982) Nasal T-cell lymphoma as a type of so-called “lethal midline granuloma.” Cancer 50:2336–2344Google Scholar
  21. Jaffe E (1984) The pathologic and clinical spectrum of postthymic T-cell malignancies. Cancer Invest 2:413–426Google Scholar
  22. Kapadia SB, Desai U, Cheng VS (1982) Extramedullary plasmacytoma of the head and neck. A clinicopathologic study of 20 cases. Medicine 61:317–329Google Scholar
  23. Li G, Hansmann ML, Lennert K (1988) Morphologie, Immunhistochemie und klinisches Verhalten maligner Lymphome und lymphomähnlicher Läsionen der Lunge. Verh Dtsch Ges Pathol 72:503–504Google Scholar
  24. Lippman SM, Grogan TM, Spier CM, Koopman CF, Gall EP, Shimm DS, Durie BGM (1987) Lethal midline granuloma with a novel T-cell phenotype as found in peripheral T-cell lymphoma. Cancer 59:936–939Google Scholar
  25. Mason DY, Gatter KC (1987) The role of immunocytochemistry in diagnostic pathology. J Clin Pathol 40:1042–1054Google Scholar
  26. Michaels L, Gregory M (1977) Pathology of “non-healing (midline) granuloma”. J Clin Pathol 30:317–327Google Scholar
  27. Ng CS, Chan JKC, Cheng PNM, Szeto SC (1986) Nasal T-cell lymphoma associated with hemophagocytic syndrome. Cancer 58:67–71Google Scholar
  28. Norton AJ, Ramsay AD, Smith SH, Beverly PCL, Isaacson PG (1980) Monoclonal antibody (UCHL1) that recognizes normal and neoplastic T cells in routinely fixed tissues. J Clin Pathol 39:399–405Google Scholar
  29. Poppema S, Hollema H, Visser L, Vos H (1987) Monoclonal antibodies (MT1, MT2, MB1, MB2, MB3) reactive with leukocyte subsets in paraffin embedded tissue sections. Am J Pathol 127(3):418–429Google Scholar
  30. Reddy S, Pellettiere E, Saxena V, Hendrickson FR (1980) Extranodal non-Hodgkin's lymphoma. Cancer 46:1925–1931Google Scholar
  31. Robbins KT, Fuller LM, Vlasak M, Osborne B, Jing BS, Velasquez WS, Sullivan JA (1985) Primary lymphomas of the nasal cavity and paranasal sinuses. Cancer 56:814–819Google Scholar
  32. Sofferman RA, Cummings CW (1975) Malignant lymphoma of the paranasal sinuses. Arch Otolaryngol 101:287–292Google Scholar
  33. Stansfeld AG, Diebold J, Kapanci Y, Kelenyi G, Lennert K, Mioduszewska O, Noel H, Rilke F, Sundstrom C, van Unnik J, Wright DH (1988) Updated Kiel classification for lymphoma. Lancet i 292–293, 603Google Scholar
  34. Stein H, Gerdes J, Schwab U, Lemke H, Mason DY, Ziegler A, Schienle W, Diehl V (1982) Identification of Hodgkin and Sternberg-Reed cells as a unique cell type derived from a newly detected small cell poputation. Int J Cancer 30:445–459Google Scholar
  35. Suchi T, Lennert K, Tu L-Y, Kikuchi M, Sato E, Stansfeld AG, Feller AC (1987) Histopathology and immunohistochemistry of peripheral T cell lymphomas: a proposal for their classification. J Clin Pathol 40:995–1015Google Scholar
  36. Wegener F (1939) Über eine eigenartige rhinogene Granulomatose mit besonderer Beteiligung des Arteriensystems und der Nieren. Ziegler's Beitr z pathol Anat 102:36–68Google Scholar
  37. West KP, Warford A, Fray L, Allen M (1986) The demonstration of B-cell, T-cell and myeloid antigens in paraffin sections. J Pathol 150:89–101Google Scholar
  38. Wilder WH, Harner SG, Banks PM (1983) Lymphoma of the nose and paranasal sinuses. Arch Otolaryngol 109:310–312Google Scholar
  39. Wong DS, Fuller LM, Butler JJ, Shullenberger CC (1975) Extranodal non-Hodgkin's lymphomas of the head and neck. Am J Roentgenol, Rad Therapy & Nuclear Med 123:471–481Google Scholar
  40. Yamanaka N, Harabuchi Y, Sambe S, Shido F, Matsuda F, Kataura A, Ishii Y, Kikuchi K (1985) Non-Hodgkin's lymphoma of Waldeyer's ring and nasal cavity. Cancer 56:768–776Google Scholar

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • Chr Fellbaum
    • 1
  • M. -L. Hansmann
    • 1
  • K. Lennert
    • 1
  1. 1.Lymph Node Registry, Institute of PathologyChristian-Albrechts-UniversityKielGermany

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