Virchows Archiv A

, Volume 413, Issue 3, pp 257–264 | Cite as

Necrotizing Tracheobronchitis: A complication of high frequency jet ventilation

  • Catherine Delafosse
  • Jean-Claude Chevrolet
  • Peter Suter
  • Jeremiah N. Cox


The tracheal and bronchial lesions observed are described in seven patients, presenting with respiratory distress syndrome and receiving both conventional and high frequency jet ventilation for various periods. The histological findings are related to the duration of the exposure as well as the number of pulsations administered to the tracheobronchial tree. Severe damage to the mucosa leading to acute tracheobronchitis, hyperplasia and hypersecretion of the mucosal glands may explain some of the clinical symptoms observed, especially the upper respiratory obstruction. Care should be taken to limit these changes which may lead to various degrees of stenosis in survivors receiving this mode of therapy.

Key words

Respiratory distress syndrome Necrotizing tracheobronchitis High frequency ventilation High frequency jet ventilation Conventional mechanical ventilation 


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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • Catherine Delafosse
    • 1
  • Jean-Claude Chevrolet
    • 2
  • Peter Suter
    • 3
  • Jeremiah N. Cox
    • 1
  1. 1.Department of PathologyFaculty of Medicine, University of GenevaGeneva 4Switzerland
  2. 2.Department of MedicineFaculty of Medicine, University of GenevaGenevaSwitzerland
  3. 3.Division of Surgical Intensive CareFaculty of Medicine, University of GenevaGenevaSwitzerland

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