Summary
In the present study, hepatic venous distribution per unit of liver surface area on normal wedge biopsies from man (n=11) and baboon (n=8) were analysed and compared. Terminal hepatic veins (THV - man:n=100; baboon:n=200) morphometric size variables were obtained with a Leitz ASM 68K morphometric equipment. THV, defined as hepatic veins up to 150 μm in internal diameter (ID), in the centrolobular position and with sinusoidal openings, represented 84% and 74% of hepatic veins of man and baboon, respectively. Four or more THV were generally found on 8 mm2 of liver surface. Transversely sectioned THV selected by the ratio IDminimum/IDmaximum >0.67, was found to be only 25% of the total THV. In baboon, THV merge with other terminal veins and the interlobular veins present sinusoidal inlets. The baboon THV wall surface (WS) and wall thickness (WT) values were higher than in man. Positive correlations between the number of mesenchymal cells (Mc) in the vein wall and wall surface of terminal hepatic veins (man: r= 0.79; baboon: r=0.83) and between wall surface and internal surface (IS) (man: r=0.80; baboon: r=0.72) were found. Two ratios were selected as the most reliable parameters: (1) for the THV wall rim, wall surface/internal surface (WS/IS - man: 0.43±0.16; baboon: 0.63±0.23), regarding transversely sectioned THV; and (2) for the evaluation of wall cell density (WS/Mc-man: 550±231; baboon: 558±183 μm2/cell) as they did not depend on THV caliber.
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References
Bateson MC, Hopwood D, Duguid HLD, Bouchier IAD (1980) A comparative trial of liver biopsy needles. J Clin Pathol 33:131–133
Bradbury S (1978) Microscopical image analysis: problems and approaches. J Micr 115:137–150
Elias H (1949) A re-examination of the structure of the mammalian liver. II. The hepatic lobule and its relation to the vascular and biliary system. Am J Anat 85:379–456
Elias H, Popper H (1955) Venous distributions in livers. AMA Arch Path 59:332–340
Hales MR, Allan JS, Hall EM (1959) Injection-corrosion studies of normal and cirrhotic livers. Am J Pathol 35:909–941
Lieber CS (1978) Pathogenesis and early diagnosis of alcoholic liver injury. Sem Med Beth Israel Hosp, Boston 298:888–893
Lieber CS (1983) Precursor lesions of cirrhosis. Alcohol Alcoholism 18:5–20
Lieber CS, DeCarli LM, Rubin E (1975) Sequential production of fatty liver, hepatitis, and cirrhosis in sub-human primates fed ethanol with adequate diets. Proc Natl Acad Sci USA 72(2):437–441
Milton JS, Tsokos JO (1983) Statistical methods in the biological and health sciences. McGraw-Hill, New York
Nakano M, Lieber CS (1982) Ultrastructure of initial stages of perivenular fibrosis in alcohol-fed baboons. Am J Pathol 106:145–155
Nakano M, Worner TM, Lieber CS (1982) Perivenular fibrosis in alcoholic liver injury: ultrastructure and histologic progression. Gastroenterology 83:777–785
Petrelli M, Scheuer PJ (1967) Variation in subcapsular liver structure and its significance in the interpretation of wedge biopsies. J Clin Pathol 20:743–748
Rappaport AM, MacPhee PJ, Fisher MM, Phillipps MJ (1983) The scarring of the liver acini (cirrhosis). Virchows Arch [A] 402:107–137
Rodbard D (1974) Statistical quality control and routine data processing for radioimmunoassays and immunoradiometric assays. Clin Chem 20(10):1255–1270
Sherlock S, Dick R, VanLeewen DJ (1984) Liver biopsy today. J Hepatol 1:75–85
Sundqvist C, Enkvist K (1987) The use of Lotus 1-2-3 in statistics. Comput Biol Med 17(6):395–399
Van Waes L, Lieber CS (1977) Early perivenular sclerosis in alcoholic fatty liver: a index of progressive liver injury. Gastroenterology 73:646–650
Worner TM, Lieber CS (1985) Perivenular fibrosis as precursor lesion of cirrhosis. JAMA 254:627–630
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Dr. Porto was supported by a fellowship from MEC-CAPES, Brazil. A grant for morphometric equipment was obtained from the Fondation pour la Recherche Médicale and from the Societé d'Hépatologie Expérimentale, 77 rue Pasteur, Lyon, France
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Cristovao Porto, L., Chevallier, M. & Grimaud, JA. Morphometry of terminal hepatic veins. Vichows Archiv A Pathol Anat 414, 129–134 (1989). https://doi.org/10.1007/BF00718592
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DOI: https://doi.org/10.1007/BF00718592