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Hemofiltration clearance of flecainide in a patient with acute renal failure

Intensive Care Medicine volume 14, pages 236–237 (1988)Cite this article

Abstract

Flecainide, a new antiarrhythmic drug, has been shown not no be removed to a significant extent by hemodialysis or peritoneal dialysis, in spite of a high renal clerance. Its systemic and hemofiltrate clearances, measured in a patient under continuous hemofiltration, were 402 and 19.7 ml/min respectively. The clearance ratio of less than 5% makes the contribution of hemofiltration to the elimination of flecainide clinically negligeable.

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Affiliations

  1. Service d'Anesthésiologie et de Réanimation, Centre Hospitalier Universitaire, Lausanne, Switzerland

    A. Borgeat, B. Freymond, M. Bayer-Berger & R. Chiolero

  2. Division de Pharmacologie Clinique, Centre Hospitalier Universitaire, Lausanne, Switzerland

    J. Biollaz

Authors
  1. A. Borgeat
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  2. J. Biollaz
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  3. B. Freymond
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  4. M. Bayer-Berger
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  5. R. Chiolero
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Borgeat, A., Biollaz, J., Freymond, B. et al. Hemofiltration clearance of flecainide in a patient with acute renal failure. Intensive Care Med 14, 236–237 (1988). https://doi.org/10.1007/BF00717997

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  • DOI: https://doi.org/10.1007/BF00717997

Key words

  • Hemofiltration
  • Flecainide
  • Atrial fibrillation
  • Pharmacokinetics
  • Renal failure