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Inhibition by vecuronium of carbachol-induced influx of22Na2+,45Ca2+ and secretion of catecholamines in cultured bovine adrenal medullary cells

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Summary

In cultured bovine adrenal medullary cells, vecuronium, pancuronium and D-tubocurarine reduced carbachol-induced45Ca2+ influx and catecholamine secretion by inhibiting22Na+ influx via nicotinic receptor-ion channel complex with IC50 values of 0.43, 7.6 and 3.9μmol/l, respectively. IC50 values of pancuronium and D-tubocurarine observed in adrenal medulla were one order of magnitude higher than the plasma concentrations of these muscle relaxants reported to produce 50% neuromuscular blockade, while IC50 of vecuronium was quite close between adrenal medulla and skeletal muscle.

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Authors and Affiliations

  1. Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, 1-1, Iseigaoka, Yahatanishiku, Kitakyushu 807, Japan

    Akihiko Wada, Masahide Arita, Hiroshi Takara, Yasuhito Uezono & Futoshi Izumi

  2. Department of Anesthesiology, Osaka University, Medical School, 1-1-50, Fukushima, Fukushimaku, Osaka 553, Japan

    Koji Sumikawa

Authors
  1. Akihiko Wada
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  2. Masahide Arita
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  3. Hiroshi Takara
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  4. Koji Sumikawa
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  5. Yasuhito Uezono
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  6. Futoshi Izumi
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Wada, A., Arita, M., Takara, H. et al. Inhibition by vecuronium of carbachol-induced influx of22Na2+,45Ca2+ and secretion of catecholamines in cultured bovine adrenal medullary cells. Naunyn-Schmiedeberg's Arch. Pharmacol. 340, 605–609 (1989). https://doi.org/10.1007/BF00717734

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  • DOI: https://doi.org/10.1007/BF00717734

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