Summary
The postnatal vascular growth in the neocortical area 18 of normal and pre- and postnatally protein-deprived rats was examined. For control rats the specific length, the specific surface and the volume fraction of vessels increased rapidly between 7 and 20 days of age. Thereafter, only a minor increase was seen. In protein-deprived rats there was no increase in the specific length of vessels between 7 and 10 days of age and this variable was still reduced at 30 days of age compared to controls. This reduction was due to a decrease in the specific length of thin vessels (Ø<8.25 μ) whereas the specific length of wider vessels was not affected by the protein deprivation. There were no significant differences in the specific surface or volume fraction of vessels between control and protein-deprived rats. These findings indicate an adaptive increase in luminal diameter of vessels in the protein deprived rats during postnatal development. At 90 days of age no significant differences between vascular variables of control and protein-deprived rats were seen.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Altman, J.: Postnatal development of the cerebellar cortex. Parts I, II and III. J. Comp. Neurol.145, 353–514 (1972)
Beas, R., Mönckeberg F., Harawitz, J.: The response of the thyroid gland to the thyroid stimulating hormone (TSH) in infants with malnutrition. Pediatrics38, 1003–1008 (1966)
Bär, Th., Wolff, J.-R.: Quantitative Beziehungen zwischen der Verzweigungsdichte und Länge von Kapillaren im Neocortex der Ratte während der postnatalen Entwicklung. Z. Anat. Entwickl. Gesch.141, 207–221 (1973)
Bär, Th., Eins, S., Nicksch, E.: Morphometrische Untersuchungen an Hirnkapillaren von Ratten nach chronischem Sauerstoffmangel. Verh. Anat. Ges.69, 131–138 (1975)
Caley, D. M., Maxwell, D. S.: Development of the blood vessels and extra cellular spaces during postnatal maturation of rat cerebral cortex. J. Comp. Neurol138, 31–48 (1970)
Campbell, A. C. F.: Variation in vascularity and oxidase content in different regions of the brain of the cat. Arch. Neurol. Psychiat. (Chicago)41, 223–242 (1939)
Conel, J. L.: The postnatal development of the human cerebral cortex, Vol. 6. The cortex of the twenty-four month infant. Cambridge, MA: Harvard University Press 1959
Conradi, N. G., Eins, S., Wolff, J.-R.: Postnatal vascular growth in cerebellar cortex of normal and protein-deprived rats. Acta Neuropathol. (Berl.)47, 131–137 (1979a)
Conradi, N. G., Engvall, J., Wolff, J.-R.: Angioarchitectonics of rat cerebellar cortex during postnatal development. (in prep.)
Cragg, B. G.: The development of cortical synapses during starvation in the rat. Brain95, 143–150 (1972)
Craigie, E. H.: The comparative anatomy and embryology of the capillary bed of the central nervous system. Proc. Assoc. Res. Nerv. Ment. Dis.18, 3–28 (1938)
Deo, M. G., Ramalingaswami, V.: Reaction of the small intestine to induced protein malnutrition in Rhesus Monkeys — a study of cell population kinetics in the jejunum. Gastroenterology49, 150–157 (1965)
Dunning, H. S., Wolff, H. G.: The relative vascularity of various parts of the central and peripheral nervous system in the cat and its relation to function. J. Comp. Neurol.67, 433–450 (1937)
Eayrs, J. T.: The vascularity of the cerebral cortex in normal and cretinous rats. J. Anat.88, 164–173 (1954)
Eins, S., Bär, Th.: Orientation distribution of blood vessels in central nervous tissue. Prakt. Metallogr.8, 381–388 (1978)
Eins, S., Wilhelms, E.: Assessment of preparative volume changes in central nervous tissue using automatic image analysis. Microscope24, 29–38 (1976)
Farkas-Bargeton, E., Diebler, M. F.: A topographical study of enzyme maturation in human cerebral neocortex: A histochemical and biochemical study. In: Architectonics of the cerebral cortex. Brazier, M. A. B., Petsche, H. (eds.). New York: Raven Press 1978
Fox, W. M., Ottilie, I. R., Himwich, W. A.: The postatal development of neocortical neurons in the dog. J. Comp. Neurol.127, 199–206 (1966)
Fox, C. A., Hillman, D. E., Siegesmund, K. A., Dutta, C. R.: The primate cerebellar cortex: A Golgi and electron microscopic study. Prog. Brain Res.25, 174–225 (1967)
Friede, R. L.: Histochemical investigation of succinic dehydrogenase in the central nervous system. I. Distribution in the developing rat's brain. J. Neurochem.4, 101–111 (1959)
Gambetti, P., Autilio-Gambetti, L., Rizzuto, M., Shafer, B., Pfaff, L.: Synapses and malnutrition: Quantitative ultrastructural study of rat cerebral cortex. Exp. Neurol.43, 464–473 (1974)
Gyllensten, L.: Influence of oxygen exposure on the postnatal vascularization of the cerebral cortex in mice. Acta Morphol. Neerl. Scand.2, 289–310 (1959a)
Gyllensten, L.: Postnatal development of the visual cortex in darkness (mice). Acta Morphol. Neerl. Scand.2, 331–345 (1959b)
Heggeness, F. W.: Nutritional status and physiological development of the preweaning rat. Am. J. Physiol.203, 545–549 (1962)
Horstmann, E.: Abstand und Durchmesser der Kapillaren im Zentralnervensystem verschiedener Wirbeltierklassen. In: Structure and function of the cerebral cortex. Tower, D. B., Schadé, J. F. (eds.), p. 59–63. Amsterdam: Elsevier 1960
Katiyar, G. P., Agarwal, K. N., Shanker, R., Nagchaudhuri, J.: Effect of protein energy deprivation on the brain enzymes of glutamic acid in preweanling rats. Nutr. Metab.20, 396–403 (1976)
Kornguth, S. E., Scott, G.: The role of climbing fibres in the formation of Purkinje cell dendrites. J. Comp. Neurol.146, 61–82 (1972)
Krieg, W. J. S.: Connection of the cerebral cortex. I. The albino rat. A. Topography of the cortical areas. J. Comp. Neurol.84, 221–275 (1946)
Leduc, E. H.: Mitotic activity in the liver of the mouse during inanition followed by refeeding with different levels of protein. Am. J. Anat.81, 397–429 (1949)
Marin-Padilla, M.: Prenatal and early postnatal ontogenesis of the human motor cortex: A Golgi study. I. The sequential development of the cortical layers. Brain Res.23, 167–183 (1970)
Muzzo, S., Gregory, T., Gardner, L. I.: Oxygen consumption by brain mitochondria of rats malnourished in utero. J. Nutr.103, 314–317 (1973)
Palay, S. L., Chan-Palay, V.: Cerebellar cortex. New York: Springer 1974
Patel, A. J., Balazs, R., Johnson, A. L.: Effect of undernutrition on cell formation in the rat brain. J. Neurochem.20, 1151–1165 (1973)
Rajalakshmi, R., Parameswaran, M., Telang, S. D., Ramakrishnan, C. V.: Effects of undernutrition and protein deficiency on glutamate dehydrogenase and decarboxylase in rat brain. J. Neurochem.23, 129–133 (1974)
Richardsson, K. C., Jarrett, L., Finke, E. H.: Embedding in epoxy resins for ultrathin sectioning in electron microscopy. Stain Technol.35, 313–323 (1960)
Saunders, R. L. de C. H., Bell, M. A.: X-ray microscopy and histochemistry of the human cerebral blood vessels. J. Neurosurg.35, 128–140 (1971)
Seil, F. Z., Kelly, J. M., Leiman, A. L.: Anatomical organization of cerebral neocortex in tissue culture. Exp. Neurol.45, 435–450 (1974)
Shoemaker, W. J., Bloom, F. E.: Effect of undernutrition on brain morphology. In: Nutrition and the brain, Vol. 2. Wurtman, R. J., Wurtman, J. J. (eds.), New York: Raven Press 1977
Siassi, F., Siassi, B.: Differential effects of protein-calorie restriction and subsequent repletion on neuronal and non neuronal components of cerebral cortex in newborn rats. J. Nutr.103, 1625–1633 (1973)
Tongiani, R.: Hepatocyte classes during liver atrophy due to starvation in the golden hamster. Z. Zellforsch.122, 467–478 (1971)
Wechsler, W.: Die Entwicklung der Gefäße und perivaskulären Gewebsräume im Zentralnervensystem von Hühnern. Z. anat. Entwickl. Gesch.124, 367–395 (1965)
Wiebecke, B., Eder, M., Heylowitz, R.: Änderungen der Epithelregeneration der Dünndarmschleimhaut der Maus im Hungerzustand. Verh. Dtsch. Ges. Pathol.52, 446–448 (1970)
Wolff, J.-R.: Ontogenetic aspects of cortical architecture: Lamination. In: Architectonics of the cerebral cortex. Brazier, M. A. B., Petsche, H. (eds.), New York: Raven Press 1978
Woodward, D. Z., Hoffer, B. J., Lapham, L. W.: Postnatal development ef electrical and enzyme histochemical activity in Purkinje cells. Exp. Neurol.23, 120–139 (1969)
Woolsley, T. A., van der Loos, H.: The relationship between glycolytic and mitochondrial enzymes in the developing rat brain. J. Neurochem.19, 223–227 (1970)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Conradi, N.G., Eins, S. & Wolff, J.R. Postnatal vascular growth in the neocortex of normal and protein-deprived rats. Acta Neuropathol 47, 123–130 (1979). https://doi.org/10.1007/BF00717035
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00717035