European Journal of Pediatrics

, Volume 146, Issue 3, pp 290–291 | Cite as

Fulminant hepatitis during treatment with Rifampicin, pyrazinamid and ethambutol

  • W. M. C. van Aalderen
  • H. Knoester
  • K. Knol
Short Communications


A 10-year-old girl with cervical tuberculosis was treated with Isoniazid, Rimfampicin and Ethambutol. After 2 weeks of treatment a hepatotoxic reaction developed. Withdrawal of therapy resulted in complete clinical improvement and in normalization of all laboratory measurements. Treatment was restarted with Rifampicin, Pyrazinamid and Ethambutol. Liver enzyme levels were monitored weekly. Seven weeks after this three-drug regiment was started, all therapy was discontinued because of elevated liver enzyme levels. However, the patient died 2 weeks later of progressive fulminant hepatitis.

Key words

Tuberculosis Tuberculostatics Hepatitis 











glutamic oxaloacetic transaminase


gammaglutamyl transpeptidase


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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • W. M. C. van Aalderen
    • 1
  • H. Knoester
    • 1
  • K. Knol
    • 1
  1. 1.Department of Paediatrics, Division of PulmonologyUniversity HospitalGroningenThe Netherlands

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