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European Journal of Pediatrics

, Volume 146, Issue 3, pp 246–250 | Cite as

131-metaiodobenzylguanedine therapy of neuroblastoma in childhood

One year of therapeutic experience
  • D. Schwabe
  • St. Sahm
  • V. Gerein
  • J. Happ
  • H. Kropp-v. Rabenau
  • F. Maul
  • R. P. Baum
  • K. Manegold
  • C. Nitz
  • G. Hör
  • B. Kornhuber
Original Investigations

Abstract

Eleven children with neuroblastoma refractory to conventional therapy or relapse of neuroblastoma were treated with 131-metaiodobenzylguanedine (MIBG). The therapeutic results and the side effects were evaluated. In one patient with disseminated bone marrow involvement complete remission was obtained. Partial remission was observed in six patients and stable disease in another. Three patients did not respond to MIBG, in two of them the tumours did not accumulate a sufficient MIBG dose. Clinical and laboratory examinations revealed an excellent tolerance of MIBG in all patients. First attempts to continue cytostasis after MIBG therapy were made. MIBG has a good therapeutic efficacy is sufficiently incorporated into the tumour cell.

Key words

Neuroblastoma 131-metaiodobenzylguanedine treatment Therapeutic effect Tolerance 

Abbreviations

MIBG

131-I-metaiodobenzylguanedine

CR

complete remission

PR

partial remission

LDH

lactate dehydrogenase

ASAT

aspartate-amino transferase

ALAT

alanine-amino transferase

Y-GT

gamma-glutamyl transpeptidase

AP

alkaline phosphatase

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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • D. Schwabe
    • 1
  • St. Sahm
    • 1
  • V. Gerein
    • 1
  • J. Happ
    • 2
  • H. Kropp-v. Rabenau
    • 1
  • F. Maul
    • 2
  • R. P. Baum
    • 2
  • K. Manegold
    • 2
  • C. Nitz
    • 2
  • G. Hör
    • 2
  • B. Kornhuber
    • 1
  1. 1.Department of Haematology and Oncology, Paediatric ClinicJ. W. Goethe-UniversityFrankfurFederal Republic of Germany
  2. 2.Department of Nuclear MedicineJ. W. Goethe-UniversityFrankfurtFederal Republic of Germany

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