Virchows Archiv A

, Volume 412, Issue 2, pp 145–149 | Cite as

Scar and non-scar ductal cancer of the female breast

Observations on patient age, tumour size, and hormone receptors
  • Seppo Partanen
  • Hannu Hyvärinen


Ductal cancers of human female breasts were classified as scar or non-scar type. Of 274 cancers, 144 were scar and 130 non-scar type. Estrogen and progesterone receptors were determined in 191 cases; the cancer was classified as hormone receptor positive if either the estrogen or progesterone receptor level, or both, was over 10 fmol/mg of cytosol protein. The mean age of patients with scar cancer was higher than that of patients with non-scar cancer (59.8 ± 13.5 and 49.4±12.0 years, respectively,p<0.001). A higher number of hormone receptor positive cases was found among the scar than among the non-scar cancers (68 of 94 and 48 of 97 cases, respectively,p<0.01). Within the two groups, the patient's age was not associated with hormone receptor status. Our results indicate that the generally observed tendency for postmenopausal breast cancer to be more often hormone receptor positive than premenopausal cancer may be associated with the histological type and not with the patient's age. Scar cancers were also smaller than 2 cm more frequently than non-scar cancers (p<0.001) and as a group, ductal cancers were smaller in postmenopausal patients than in premenopausal patients (p=0.088). Again, this tendency seemed to be linked with the type of cancer rather than with the patient's age.

Key words

Breast cancer Scar type Patient age Tumour size Hormone receptors 


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  1. Andersen JA, Gram JB (1984) Radial scar in the female breast. A long-term follow-up study of 32 cases. Cancer 53:2557–2560Google Scholar
  2. Anderson TJ, Ferguson DJP, Raab GM (1982) Cell turnover in the “resting” human breast: Influence of parity, contraceptive pill, age and laterality. Br J Cancer 46:376–382Google Scholar
  3. Azzopardi JG (1979) Problems in Breast Pathology. In: Bennington JL (ed) Major problems in pathology, vol 11. WB Saunders, PhiladelphiaGoogle Scholar
  4. Bresciani F (1971) Ovarian steroid control of cell proliferation in the mammary gland and cancer. In: Hubinot PO, Leroy F, Galand P (eds) Basic actions of sex steroids on target organs. Karger, Basel, pp 130–159Google Scholar
  5. Fenoglio C, Lattes R (1974) Sclerosing papillary proliferations in the female breast: A benign lesion often mistaken for carcinoma. Cancer 33:691–700Google Scholar
  6. Fisher ER, Palekar AS, Sass R, Fisher B (1983) Scar cancers: pathologic findings from the National Surgical Adjuvant Breast Project (Protocol No 4)-IX. Breast Cancer Res Treat 3:39–59Google Scholar
  7. Fisher ER, Redmond CK, Liu H, Rockette H, Fisher B, and collaborating NSABP investigators (1980) Correlation of estrogen receptor and pathologic characteristics of invasive breast cancer. Cancer 45:349–353Google Scholar
  8. Foote FW, Stewart FW (1946) A histologic classification of carcinoma of the breast. Surgery 19:74–99Google Scholar
  9. Glaubitz LC, Bowen JH, Cox EB, McCarty KS (1984) Elastosis in human breast cancer. Arch Pathol Lab Med 108:27–30Google Scholar
  10. Hamperl H (1975) Strahlige Narben und obliterierende Mastopathie: Beiträge zur pathologischen Histologie der Mamma. XI. Virchows Arch [A] 369:55–68Google Scholar
  11. Jensen EV (1975) Estrogen receptors in hormone-dependent breast cancers. Cancer Res 35:3362–3364Google Scholar
  12. Knight WA, Osborne CK, McGuire WL (1980) Hormone receptors in primary and advanced breast cancer. In: Abe K (ed) Clinics in endocrinology and metabolism, vol 9:2: Endocrinology and cancer. WB Saunders, London, pp 361–368Google Scholar
  13. Lesser ML, Rosen PP, Senie RT, Duthie K, Menendez-Botet C, Schwartz MK (1981) Estrogen and progesterone receptors in breast carcinoma: Correlations with epidemiology and pathology. Cancer 48:299–309Google Scholar
  14. Lima-De-Almeida FM, Brentani MM, Velludo MASL, Goes JCS, Baruffi I (1985) Elastosis and steroid receptors in primary breast cancer. Braz J Med Biol Res 18:279–283Google Scholar
  15. Linell F, Ljungberg O, Andersson I (1980) Breast carcinoma. Aspects of early stages, progression and related problems. Acta Pathol Microbiol Immunol Scand [A] Suppl 272:1–233Google Scholar
  16. Linell F, Ljungberg O, Andersson I (1981) Brustkarzinom. Frühstadien, Progression und verwandte Probleme. Pathologe 2:150–155Google Scholar
  17. Masters JRW, Drife JO, Scarisbrick JJ (1977) Cyclic variation of DNA synthesis in human breast epithelium. J Natl Cancer Inst 58:1263–1265Google Scholar
  18. Masters JRW, Sangster K, Hawkins RA, Shivas AA (1976) Elastosis and oestrogen receptors in human breast cancer. Br J Cancer 33:342–343Google Scholar
  19. Meyer JS (1977) Cell proliferation in normal human breast ducts, fibroadenomas, and other ductal hyperplasias measured by nuclear labeling with tritiated thymidine. Hum Pathol 8:67–81Google Scholar
  20. Millis RR (1980) Correlation of hormone receptors with pathological features in human breast cancer. Cancer 46:2869–2871Google Scholar
  21. Stanford JL, Szklo M, Brinton LA (1986) Estrogen receptors and breast cancer. Epidemiol Rev 8:42–59Google Scholar
  22. Vorherr H (1980) Breast cancer. Epidemiology, endocrinology, biochemistry and pathobiology. Urban & Schwarzenberg, BaltimoreGoogle Scholar
  23. Wellings SR (1980) A hypothesis of the origin of human breast cancer from the terminal ductal lobular unit. Pathol Res Pract 166:515–535Google Scholar
  24. Wittliff JL (1984) Steroid-hormone receptors in breast cancer. Cancer 53:630–643Google Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • Seppo Partanen
    • 1
  • Hannu Hyvärinen
    • 1
  1. 1.Department of PathologyJorvi HospitalEspooFinland

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