Abstract
The conductance of aqueous solutions of sodium glycodeoxycholate and sodium taurodeoxycholate displays a complex concentration dependence (0–0.5 C) with a maximum and minimum occurring in dilute solutions. This behavior can be related to physiologic concentrations observed in hepatic and gallbladder bile and interpreted in terms of anion dimerization and ultimately micellization. The addition of lecithin in 1:2 or 1:5 molar ratios results in micellization at lower concentration, disappearance of the maximum and minimum in the conductance curve, and a decrease in the total conductance.
Similar content being viewed by others
References
A. F. Hofmann and D. M. Small,Ann. Rev. Med. 18, 333 (1967).
D. M. Small,Advan. Chem. Ser., No. 84, 31 (1968).
M. C. Carey and D. M. Small,J. Colloid Interface Sci. 31, 382 (1969).
F. P. Woodford,J. Lipid Res. 10, 539 (1969).
B. Isaksson,Acta Soc. Med. Upsalien. 59, 277 (1954).
D. H. Neiderhiser and H. P. Roth,Proc. Soc. Exp. Biol. Med. 128, 221 (1968).
D. M. Small, S. A. Penkett, and D. Chapman,Biochim. Biophys. Acta 176, 178 (1969).
W. Shankland,Chem. Phys. Lipids 4, 109 (1970).
J. T. Bashour and L. Bauman,J. Biol. Chem. 121, 1 (1937).
R. R. Roepke and H. L. Mason,J. Biol. Chem. 133, 103 (1940).
O. Mellander and E. Stenhagen,Acta Physiol. Scand. 4, 349 (1942).
S. A. Johnston and J. W. McBain,Proc. Roy. Soc. (London), Ser. A,181, 119 (1943).
P. Ekwall,Acta Acad. Aboensis, Math. Phys. 17, No. 8 (1951).
A. Norman,Acta Chem. Scand. 14, 1300 (1960).
E. L. Cussler, D. F. Evans, and R. G. DePalma,Proc. Nat. Acad. Sci. 67, 400 (1970).
J. Usai,J. Biochem. 54, 283 (1963).
D. M. Small, M. C. Bourges, and D. G. Dervichian,Biochim. Biophys. Acta 125, 563 (1966).
R. L. Kay, B. J. Hales and G. P. Cunningham,J. Phys. Chem. 71, 3925 (1967).
C. G. Swain and D. F. Evans,J. Am. Chem. Soc. 88, 383 (1966); D. F. Evans and P. Gardam,J. Phys. Chem. 73, 158 (1969).
P. Mukerjee, K. J. Mysels, and C. I. Dulin,J. Phys. Chem. 62, 1390 (1958); P. Mukerjee,J. Phys. Chem. 62, 1404 (1958).
R. M. Fuoss and F. Accascina,Electrolytic Conductance (Interscience Publishers, Inc., New York, 1959).
Y. C. Chiu and R. M. Fuoss,J. Phys. Chem. 72, 4123 (1968).
T. L. Broadwater and D. F. Evans,J. Phys. Chem. 73, 3985 (1969).
C. W. Hoerr and A. W. Ralston,J. Am. Chem. Soc. 65, 976 (1943); M. E. L. McBain,J. Phys. Chem. 47, 196 (1943).
W. F. Pfeiffer, Ph.D. Thesis, Department of Chemistry, Case Western Reserve University, September 1970; K. Fontell, inSurface Chemistry, P. Ekwallet al., eds. (Munkegoard, Copenhagen, 1965, p. 252.
C. Treiner and R. M. Fuoss,J. Phys. Chem. 69, 2576 (1965).
W. H. Admirand and D. M. Small,J. Clin. Invest. 47, 1043 (1968); R. G. DePalma, P. H. Hartman, and J. D. McCue,Abs. Clin. Res. 12, 525 (1969).
G. Atkinson and H. Hallada,J. Am. Chem. Soc. 83, 3759 (1961); G. Atkinson, M. Yokoi, and C. J. Hallada,J. Am. Chem. Soc. 83, 1570 (1961).
G. D. Parfitt and A. L. Smith,Trans. Faraday Soc. 61, 2736 (1965).
E. L. Cussler and C. Duncan,J. Solution Chem. 1, 269 (1972).
A. S. C. Lawrence and J. T. Pearson,Trans. Faraday Soc. 63, 495 (1967).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Evans, D.F., DePalma, R., Nadas, J. et al. The conductance of bile salt-lecithin-water mixtures. J Solution Chem 1, 377–386 (1972). https://doi.org/10.1007/BF00715995
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00715995