Molecular and Cellular Biochemistry

, Volume 155, Issue 1, pp 43–49 | Cite as

Gender-related regional antioxidant profiles in the gastrointestinal tract of the rat

  • Mohammed H. Moghadasian
  • David V. Godin


This study compared the activities of the antioxidant enzymes glutathione peroxidase, glutathione reductase and superoxide dismutase and the levels of glutathione in the mucosa of the body of the stomach, proximal and distal parts of the small intestine and the colon in male and female Sprague Dawley rats. Basal glutathione levels were significantly (p < 0.05) higher in the small intestine as compared with those in the other portions studied in both sexes. Except for colonic mucosa in females, the activity of glutathione reductase was similar in all the other tissues examined. Glutathione peroxidase showed the largest regional differences, with activities in the gastric segment being several-fold greater than those in small intestine or colon. This enzyme also showed marked gender-related differences, activity being greater in females than males in gastric mucosa and colon, while the converse was true for distal small intestine. In contrast, activities of superoxide dismutase showed minimal regional or gender-dependent variations.

Key words

gastrointestinal mucosa glutathione glutathione peroxidase glutathione reductase superoxide dismutase 


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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Mohammed H. Moghadasian
    • 1
  • David V. Godin
    • 1
  1. 1.Department of Pharmacology & Therapeutics, Faculty of MedicineThe University of British Columbia, 2176 Health Sciences MallCanada

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