European Radiology

, Volume 2, Issue 1, pp 57–61 | Cite as

Infantile hypopituitarism: etiological variability evidenced by MRI

  • M. -H. Smet
  • F. de Zegher
  • M. Vanderschueren-Lodeweyckx
  • G. Marchal
Original articles Pediatric radiology

Abstract

In this study, magnetic resonance imaging (MRI) was performed to document potentially present morphostructural abnormalities of the hypothalamopituitary region in seven infants (age 0–21 months) who presented very early in life with clinical and biochemical evidence of hypopituitarism. Four infants had associated congenital cerebro-facial malformations.

The following anatomical abnormalities were identified in variable combinations: ectopic neurohypophysis absence of the pituitary stalk, extreme elongation of the pituitary stalk, aplasia of the anterior pituitary lobe and no identification of the hypothalamopituitary complex.

MRI proved to be very sensitive in the identification of structural malformations of the hypothalamopituitary region in infants with or without cerebro-facial malformations. AllhwuLll the magnetic resonance image does not appear to be a good predictor of endocrine dysfunction, it provides us more insight into the precise aetiology of this disorder and may be therefore of diagnostic, prognostic and therapeutic importance.

Key words

Magnetic resonance imaging Pituitary MR studies Hypopituitarism Growth disorders Diabetes insipidus 

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References

  1. 1.
    Karnaze MG, Sartor K, Winthrop JD, Gado MH, Hodges III FJ (1986) Suprasellar lesions: evaluation with MR imaging. Radiology 161: 77–82Google Scholar
  2. 2.
    Lee BCP, Deck MDF (1985) Sellar and juxtasellar lesion detection with MR. Radiology 157: 143–147Google Scholar
  3. 3.
    Sartor K, Karnaze MG, Winthrop JD, Gado M, Hodges III FJ (1987) Magnetic resonance imaging in infra-, para- and retrosellar mass lesions. Neuroradiology 29: 19–29Google Scholar
  4. 4.
    Mark L, Peck P, Daniels D, Charles C, Williams A, Haughton VM (1984) The pituitary fossa: a correlative anatomic and MR study. Radiology 153: 453–457Google Scholar
  5. 5.
    Nishimura K, Fujisawa I, Togashi I, Itoh K, Vakano Y, Itoh H, and Torizuka K (1986) Posterior lobe of the pituitary: identification by lack of chemical shift artifact in MRI. J Comput Assist Tomogr 10: 899–902Google Scholar
  6. 6.
    Fujisawa I, Asato R, Nishimura K, Togashi K, Itoh K, Nakano Y, Itoh H, Hashimoto N, Takeuchi J, and Torizuka K (1987) Anterior and posterior lobes of the pituitary gland: assessment by 1.5 T MR imaging. J Comput Assist Tomogr 11: 214–220Google Scholar
  7. 7.
    Fujisawa I, Nishimura K, Asato R, Togashi K, Itoh K, Noma S, Kawamura Y, Sago T, Minami S, Nakano Y, Itoh H, and Torizuka K (1987) Posterior lobe of the pituitary in diabetes insipidus: MR findings. J Comput Assist Tomogr 11: 221–225Google Scholar
  8. 8.
    Wolpert SM, Osborne M, Anderson M, Runge VM (1988) The bright pituitary gland — a normal MR appearance in infancy. AJNR 9: 1–3Google Scholar
  9. 9.
    Gudinchet F, Brunelle F, Barth MO, Taviere V, Brauner R, Rappaport R, Lallemand D (1989) MR imaging of the posterior hypophysis in children. AJNR 10: 511–514Google Scholar
  10. 10.
    Cox TD, Elster AD (1991) Normal pituitary gland: changes in shape, size, and signal intensity during the 1st year of life at MR imaging. Radiology 179: 721–724Google Scholar
  11. 11.
    Nishimura K, Fujisawa I, Togashi K, Itoh K, Nakano Y, Itoh H, Torizuka K (1986) Posterior lobe of the pituitary: identification by lack of chemical shift artifact in MR imaging. J Comput Assist Tomogr 10 (6): 899–902Google Scholar
  12. 12.
    Colombo N, Berry I, Kucharczyk J, Kucharczyk W, de Groot J, Larson T, Norman D, H. Newton T (1987) Posterior pituitary gland: appearance on MR images in normal and pathologic states. Radiology 165: 481–485Google Scholar
  13. 13.
    Fujisawa I, Kikuchi K, Nishimura K, Togashi K, Itoh K, Noma S, Minami S, Sagoh T, Hiraoka T, Momoi T, Mikawa H, Nakano Y, Itoh H, Konishi J (1987) Transection of the pituitary stalk: development of an ectopic posterior lobe assessed with MR imaging. Radiology 165: 487–489Google Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • M. -H. Smet
    • 1
  • F. de Zegher
    • 2
  • M. Vanderschueren-Lodeweyckx
    • 2
  • G. Marchal
    • 1
  1. 1.Department of RadiologyUniversity Hospitals K.U. LeuvenLeuvenBelgium
  2. 2.Department of PediatricsUniversity Hospitals K. U. LeuvenLeuvenBelgium

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