Pathophysiological approach to stroke therapy

  • G. L. Lenzi
  • M. Altieri
  • G. Bruti
  • S. Di Legge
  • D. Lenzi
  • I. Pestalozza
  • D. Tombari
  • E. Vicenzini
  • V. Di Piero
Physiopathology of Cerebrai Ischaemia
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Keywords

Ischemic Stroke Streptokinase Acute Ischemic Stroke Ischemic Penumbra Middle Cerebral Artery Territory 

References

  1. 1.
    Lassen NA, Fieschi C, Lenzi GL (1991) Ischemic penumbra and neuronal death: Comments on the therapeutic window in acute stroke with particular reference to thrombolytic therapy. Cerebrovasc Dis 1 [Suppl 1]:32–35CrossRefGoogle Scholar
  2. 2.
    Baron JC, von Kummer R, del Zoppo GJ (1995) Treatment of acute ischemic stroke. Stroke 26:2219–2221PubMedGoogle Scholar
  3. 3.
    Bamford J, Sandercock P, Dennis M, Burn J, Warlow C (1991) Classification and natural history of cerebral infarction. Lancet 337:1521–1526PubMedCrossRefGoogle Scholar
  4. 4.
    Pinto AN, Melo TP, Lourenco ME, Leandro MJ, Brazio A, Carvalho L, Franco AS, Ferro JM (1998) Can a clinical classification of stroke predict complications and treatments during hospitalization? Cerebrovasc Dis 8(4):204–209PubMedCrossRefGoogle Scholar
  5. 5.
    Fieschi C, Argentino C, Lenzi GL, Sacchetti ML, Toni D, Bozzao L (1989) Clinical and instrumental evaluation of patients with ischemic stroke within the first six hours. J Neurol Sci 91(3):311–321PubMedCrossRefGoogle Scholar
  6. 6.
    Dyker AG, Less KR (1998) Duration of neuroprotective treatment for ischemic stroke. Stroke 29:535–542.PubMedGoogle Scholar
  7. 7.
    Rothrock JF, Clark WM, Lyden PD (1995) Spontaneous rearly improvement following ischemic stroke. Stroke 26:1358–1360PubMedGoogle Scholar
  8. 8.
    Chiu D, Kriger D, Villar-Cordova C, Kasner SE, Morgenstern LB, Bratina PL, Yatsu FM, Grotta JC (1998) Intravenous tissue piasminogen activator for acute ischemic stroke. Feasibility, safety, and efficacy in the first year of clinical practice. Stroke 29:18–22PubMedGoogle Scholar
  9. 9.
    Toni D, Fiorelli M, Zanette EM, Sacchetti ML, Salerno A, Argentino C, Solaro M, Fieschi C (1998) Early spontaneous improvement and deterioration of ischemic stroke patients. A serial study with transcranial Doppler ultrasonography. Stroke 29:1144–1148PubMedGoogle Scholar
  10. 10.
    Hacke W, Kaste M, Fieschi C, Toni D, Lesaffre E, von Kummer R, Boysen G, Bluhmki E, Hoxter G, Mahange M, Hennerici M (1995) Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS). JAMA 274:1017–1025.PubMedCrossRefGoogle Scholar
  11. 11.
    Multicenter Acute Stroke Trial-Italy (MAST-I) Group (1995) Randomised controlled trial of stroptokinase, aspirin, and combination of both in treatment of acute ischemic stroke. Lancet 346:1509–1514Google Scholar
  12. 12.
    The Multicenter Acute Stroke Trial-Europe Study Group (1996) Thrombolytic therapy with streptokinase in acute ischemic stroke. N Engl J Med 18;335(3):145–150CrossRefGoogle Scholar
  13. 13.
    Donnan GA, Davis SM, Chambers BR, Gates PC, Hankey GJ, McNeil JJ, Rosen D, Stewart-Wynne EG, Tuck RR (1996) Streptokinase for acute ischemic stroke with relationship to time of administration: australian Streptokinase (ASK) Trial Study Group. JAMA 25;276(12):961–966CrossRefGoogle Scholar
  14. 14.
    von Kummer R, Holle R, Rosin L, Forsting M, Hacke W (1995) Does arterial recanalization improve outcome in carotid territory stroke? Stroke 26:581–587.Google Scholar
  15. 15.
    del Zoppo GJ, Higashida RT, Furlan AJ, Pessin MS, Rowely HA, Gent M, and the PROACT investigators (1998) PROACT: A phase II randomized trial of recombinat prourokinase by direct arterial delivery in acute middile cerebral artery stroke. Stroke 29:4–11PubMedGoogle Scholar
  16. 16.
    The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group (1995) Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 333:1581–1587CrossRefGoogle Scholar
  17. 17.
    Sandercock P (1998) What questions can large, simple trials answer? Cerebrovasc Dis 8 (S2):30–36PubMedCrossRefGoogle Scholar
  18. 18.
    Sacchetti ML, Toni D, Fiorelli M, Argentino C, Fieschi C (1997) The concept of combination therapy in acute ischemic stroke. Neurology 49[Suppl 4]:S1-S5Google Scholar
  19. 19.
    Grotta J (1997) Lubeluzole treatment of acute ischemic stroke. Stroke 28:2338–2346PubMedGoogle Scholar
  20. 20.
    Hacke W (1998) The results of the European Cooperative Stroke Sudy II (ECASS II), a placebo-controlled, randomized study of trombolytic therapy. Eur Neurol 5[Suppl 3]:59Google Scholar
  21. 21.
    Lenzi GL, Grigoletto F, Gent M, Roberts RS, Walker MD, Easton DJ, Carolei A, Dorsey FC, Rocca WA, Bruno R, Patarnello F, Fieschi C (1994) Early treatment of stroke with Monosialogangloside GM-1. Efficay and safety results of the early stroke trial. Stroke 25:1552–1558PubMedGoogle Scholar
  22. 22.
    Baron JC, Marchal G (1996) SPECT using 99mTc-HMPAO versus neurological scales to predict outcome of acute cerebral infarction. Stroke 27:1253–1254PubMedGoogle Scholar
  23. 23.
    CAST (Chinese Acute Stroke Trial) Collaborative Group (1997) CAST: randomised placebo-controlled trial of early aspirin use in 20 000 patients with acute ischemic stroke. Lancet 349:1641–1649CrossRefGoogle Scholar
  24. 24.
    Marchal G, Furlan M, Beadouin V, Rioux P, Hauttement JL, Serrati C, de la Sayette V, Le Doze F, Viader F, Derlon JM, Baron JC (1996) Early spontaneous hyperperfusion after stroke. A marker of favourable tissue outcome? Brain 119[Pt2]:409–419PubMedCrossRefGoogle Scholar
  25. 25.
    Feeney DM, Baron JC (1986) Diaschisis. Stroke 17:817–830PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1998

Authors and Affiliations

  • G. L. Lenzi
    • 1
  • M. Altieri
    • 1
  • G. Bruti
    • 1
  • S. Di Legge
    • 1
  • D. Lenzi
    • 1
  • I. Pestalozza
    • 1
  • D. Tombari
    • 1
  • E. Vicenzini
    • 1
  • V. Di Piero
    • 1
  1. 1.Department of Neurological SciencesUniversity of Roma “La Sapienza”RomaItaly

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