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Plexiform neurilemoma: A clinicopathological and immunohistochemical analysis of 23 tumours from 20 patients

Virchows Archiv A volume 411, pages 305–309 (1987)Cite this article

Summary

A clinicopathological and immunohistochemical study was done on 23 plexiform (multinodular) neurilemomas excised from 20 Japanese. Ages of the subjects ranged from 2 years to 69 years with a mean age of 30 years. The tumours occurred most often on the trunk (14), and were located commonly in the dermis and subcutis (19). Three lesions apparently originated from the peripheral nerve trunks. Multiple tumours were observed in six instances, and two were associated with von Recklinghausen's disease. Microscopically, they appeared as multinodular growths, most nodules were moderately cellular, and both Antoni A and B patterns were distinct in 10 tumours. Obvious Verocay bodies were noted in seven tumours and abortive ones in five. Immunohistochemical reactivity to S-100 protein was demonstrated in both nuclei and cytoplasm of almost all tumour cells of all lesions examined. Recurrences are nil among the 4 patients who could be followed. Correlations with trauma and with von Recklinghausen's disease are briefly discussed.

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Authors and Affiliations

  1. Second Department of Pathology, Faculty of Medicine, Kyushu University, 60,3-1-1 Maidashi, Higashi-ku, 812, Fukuoka, Japan

    Toshimitsu Iwashita & Munetomo Enjoji

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  1. Toshimitsu Iwashita
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  2. Munetomo Enjoji
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Iwashita, T., Enjoji, M. Plexiform neurilemoma: A clinicopathological and immunohistochemical analysis of 23 tumours from 20 patients. Vichows Archiv A Pathol Anat 411, 305–309 (1987). https://doi.org/10.1007/BF00713373

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  • DOI: https://doi.org/10.1007/BF00713373

Key words

  • Peripheral nerve sheath tumour
  • Plexiform neurilemoma
  • S-100 protein