Chromosome Research

, Volume 3, Issue 5, pp 281–284 | Cite as

High frequency of mutagen-induced chromatid exchanges at interstitial telomere-like DNA sequence blocks of Chinese hamster cells

  • José Luis Fernández
  • Jaime Gosálvez
  • Vicente Goyanes


Interstitial telomere-like DNA sequence arrays of Chinese hamster Don cells were delineated by fluorescencein situ hybridization in quadriradial and triradial chromosome configurations induced by X-rays, mitomycin C and teniposide (VM-26). Around 40% of the scored exchanges involved a telomeric-like block of sequences at a rearrangement site. This frequency was independent of the DNA-damaging agent, and the result suggests a general recombinogenic capacity of interstitial telomere-like DNA sequence repeats that, at least in the case of the agents employed, seems not to be related to the initial mechanism of DNA damage.

Key words

chromosome aberrations FISH ionizing radiation mitomycin C telomere sequences teniposide (VM-26) 


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Copyright information

© Rapid Communications of Oxford Ltd 1995

Authors and Affiliations

  • José Luis Fernández
    • 1
  • Jaime Gosálvez
    • 3
  • Vicente Goyanes
    • 2
  1. 1.the Centro Oncológico de GaliciaLa CoruñaSpain
  2. 2.the Unidad de GenéticaHospital ‘Teresa Herrera’La CoruñaSpain
  3. 3.the Unidad de Genética, Departmento de BiologíaUniversidad Autónoma de MadridMadridSpain

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