Summary
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1.
Carboxypeptidase H is one of several proteolytic processing enzymes required for conversion of large neuropeptide precursors into the small peptide neurotransmitters and hormones.
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2.
Because of the importance of posttranslational processing as a regulatory step for the production of active peptides, recent studies investigating control mechanisms for carboxypeptidase H (CPH) are reviewed.
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3.
Evidence is discussed which illustrates how CPH can be inhibited and activiated. These findings suggest that a processing enzyme can play a role in the control of neuropeptide production.
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4.
It will be important in further studies to understand how the multiple processing enzymes—endopeptidase(s) and aminopeptidase, along with CPH—are coordinately regulated for the synthesis of active peptides.
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Hook, V.Y.H. Regulation of carboxypeptidase H by inhibitory and stimulatory mechanisms during neuropeptide precursor processing. Cell Mol Neurobiol 8, 49–55 (1988). https://doi.org/10.1007/BF00712911
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DOI: https://doi.org/10.1007/BF00712911