Summary
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1.
This report is a tribute to Dr. Julius Axelrod, in whose laboratory the author worked as a research associate from 1971–1974.
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Work on the regulation of dopamineβ-hydroxylase and phenylethanolamine N-methyl transferase is reviewed, particularly studies showing how transsynaptic and hormonal factors regulate enzyme synthesis and degradation respectively.
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Work taking place in the author's laboratory is reviewed with respect to the influence Dr. Axelrod had on the author and his subsequent work.
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References
Allgren, R. L., Kyncl, M. M. A., and Ciaranello, R. D. (1985). Pharmacological characterization of solubilized 5HT1 serotonin binding sites from bovine brain.Brain Res. 34877–85.
Berenbeim, D. M., Wong, D. L., Masover, S. J., and Ciaranello, R. D. (1979). Regulation of the synthesis and degradation of rat adrenal phenylethanoamine N-methyltransferase. III. Stabilization of the enzyme against thermal and tryptic degradation by S-adenosylmethionine.Mol. Pharmacol. 16482–490.
Boehme, R. E., and Ciaranello, R. D. (1983). Genetic control of dopamine and serotonin receptors in inbred mice.Brain Res. 266(1): 51–63.
Ciaranello, R. D. (1978). Regulation of phenylethanolamine N-methyltransferase in rat adrenal glands. I. Regulation of enzyme synthesis and degradation by adrenal glucocorticoids.Mol. Pharmacol. 14478–489.
Ciaranello, R. D., and Axelrod, J. (1973). Genetically controlled alteration in the rate of degradation of phenylethanolamine N-methyltransferase.J. Biol. Chem. 2485616–5623.
Ciaranello, R. D., Hoffman, H., Shire, J. G. M., and Axelrod, J. (1974a). Genetic regulation of the catecholamine biosynthetic enzymes. II. Inheritance of tyrosine hydroxylase, dopamineβ-hydroxylase and phenylethanolamine N-methyltransferase.J. Biol. Chem. 2494528–4534.
Ciaranello, R. D., Lipsky, A., and Axelrod, J. (1974b). Association between fighting behavior and catecholemine biosynthetic enzymes in two sublines of an inbred mouse strain.Proc. Nat. Acad. Sci. USA 713006–3008.
Ciaranello, R. D., Wooten, G. F., and Axelrod, J. (1975). Regulation of dopamineβ-hydroxylase in rat adrenal galnds.J. Biol. Chem. 2503204–3211.
Ciaranello, R. D., Wong, D. L., and Berenbeim, D. M. (1978). Regulation of phenylethanolamine N-methyltransferase in rat adrenal glands. II. Control of PNMT thermal stability by an endogenous stabilizing factor.Mol. Pharmacol. 14490–501.
Hamblin, M. W., Ariani, K., Adriaensens, P. I., and Ciaranello, R. D. (1987). [3H]-dihydroergotamine as a high affinity, slowly dissociating radioligand for 5HT1b binding sites in rat brain membranes: Evidence for guanine nucleotide regulation fo agonist affinity states.J. Pharmacol. Exp. Ther. (in press).
Masover, S. J., Berenheim, D. M., and Ciaranello, R. D. (1979). Regulation of the synthesis and degradation of rat adrenal phenylethanolamine N-methyltransferase. IV. Synergistic stabilization of the enzyme against themal and tryptic degradation by S-adenosylmethionine and biogenic amine substrates.Mol. Pharmol. 16491–503.
Speedie, M. K., Wong, D. L., and Ciaranello, K. D. (1985). Characterization of the structure of dopamineβ-hydroxylase by anion-exchange high performance liquid chromatography.J. Chromatogr. 327351–357.
VandenBerg, S. R., Allgren, R. L., Todd, R. D., and Ciaranello, K. D. (1983). Solubilization and characterization of high-affinity [3H]serotonin binding sites from bovine cortical membranes.Proc. Natl. Acad. Sci. USA 803508–3512.
Wong, D. L., and Ciaranello, R. D. (1982). Regulatory aspects of S-adenosylmethionine in the periphery and CNS. InBiochemistry of S-Adenosylmethionine and Related Compounds (E. Usdin, R. Borchardt, and C. R. Creveling, Eds.), Macmillan, New York, pp. 461–469.
Wong, D. L., Masover, S. J., and Ciaranello, E. D. (1981). Regulation of dopamineβ-hydroxylase synthesis and degradation. III. Ascorbic acid stabilization of the enzyme.J. Biol. Chem. 256695–700.
Wong, D. L., Zager, E. L., and Ciaranello, R. D. (1982). Effects of hypophysectomy and dexamethasone administration on central and peripheral S-adenosylmethionine levels.J. Neurosci. 2758–764.
Wong, D. L., Hayashi, R. J., and Ciaranello, R. D. (1985). Regulation of biogenic amine methyltransferases by glucocorticoids via S-adenosylmethionine and its metabolizing enzymes, methionine adenosyltransferase and S-adenosylhomocysteine hydrolase.Brain Res. 330351–357.
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Ciaranello, R.D. Neurotransmitter enzyme and receptor regulation: A look back. Cell Mol Neurobiol 8, 41–48 (1988). https://doi.org/10.1007/BF00712910
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DOI: https://doi.org/10.1007/BF00712910