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Immunohistological analysis of Rosai-Dorfman histiocytosis

A disease of S-100 + CD1-histiocytes

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Summary

Five cases of Rosai-Dorfman histiocytosis (RDH) (also called Sinus Histiocytosis with Massive Lymphoadenopathy; SHML) have been studied by immunohistochemical methods with heteroantisera and monoclonal antibodies. One case was also studied by Southern blot hybridization analysis with DNA probes specific for T cell receptor beta chain and immunoglobulin heavy chain. Immunophenotyping of large histiocytes, characteristic of RDH, evidenced the presence of S-100 protein and the absence of CD1 and other markers usually found in histiocytes and macrophages. DNA hybridization study showed the absence of clonal T or B lymphoid populations.

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Bonetti, F., Chilosi, M., Menestrina, F. et al. Immunohistological analysis of Rosai-Dorfman histiocytosis. Vichows Archiv A Pathol Anat 411, 129–135 (1987). https://doi.org/10.1007/BF00712736

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