Plasma dopamine-β-hydroxylase and preschool behavior in children with conduct disorder
The preschool behavior history and a history of abuse or neglect were compared between emotionally disturbed boys with and without conduct disorder (CD), and between boys with high and low plasma dopamine-β-hydroxylase (DβH) activities and CD. Boys with CD had the expected increase in preschool behaviors associated with attention deficit disorder (ADD) and CD as well as more reports of abuse or neglect. A higher percentage of boys with low DβH were reported to have preschool behaviors associated with ADD. In contrast, more high DβH subjects were reported as abused or neglected.
Key WordsConduct Disorder Dopamine-β-Hydroxylase Abuse
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- 1.Rogeness GA, Maas JW, Javors MA, Macedo CA, Harris WR, Hoppe SK: Diagnosis, catecholamine metabolism, and plasma dopamine-β-hydroxylase.J Am Acad Child Adolesc Psychiatry 27:121–125, 1988.Google Scholar
- 2.Ciaranello RD, Boehme RE: Biochemical genetics of neurotransmitter enzymes and receptors: relationships to schizophrenia and other major psychiatric disorders.Clin Genet 19:358–372, 1981.Google Scholar
- 3.Weinshilboum, RM: Biochemical genetics of catecholamines in man.Mayo Clin Proc 58:319–330, 1983.Google Scholar
- 4.Weinshilboum RM, Raymond FA, Elveback LR, Weidman WH: Serum dopamine-β-hydroxylase activity: sibling-sibling correlation.Science 181:943–945, 1973.Google Scholar
- 5.Rogeness GA, Amrung SA, Hoppe, SK: Near-zero plasma dopamine-β-hydroxylase and conduct disorder in emotionally disturbed boys.J Am Acad Child Adolesc Psych 25:521–527, 1986.Google Scholar
- 6.Quay HC: Attention deficit disorder and the behavioral inhibition system: The relevance of the neuropsychological theory of Jeffrey A. Gray. (To appear in a supplement toJ Child Psychol Psych).Google Scholar
- 7.Campbell SB, Werry JS: Attention deficit disorder (hyperactivity). In: HC Quay & SS Werry (Eds.)Psychopathological Disorders of Childhood. New York: John Wiley and Sons. pp. 111–155, 1986.Google Scholar
- 8.Kazdin AE:Conduct Disorders in Childhood and Adolescence. Beverly Hills: Sage Publications, 1987.Google Scholar
- 9.Rogeness GA, Suchakorn A, Amrung SA, Macedo CA, Harris WR, Fisher C: psychopathology in abused or neglected children.J Am Acad Child Psych 25:659–665, 1986.Google Scholar
- 10.Rogeness GA, Javors MA, Macedo CA, Fisher C: Plasma dopamine-β-hydroxylase, HVA, MHPG and conduct disorder in emotionally disturbed boys.Biol Psychiatry 22:1158–1162, 1987.Google Scholar
- 11.Nagatsu T, Udenfriend S: Photometric assay of dopamine-β-hydroxylase activity in human blood.Clin Chem 18:980–983, 1972.Google Scholar
- 12.Herjanic B, Campbell W: Differentiating psychiatrically disturbed children on the basis of a structured interview.J Abnorm Child Psychol. 5:127–134, 1977.Google Scholar