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Cellular and Molecular Neurobiology

, Volume 13, Issue 6, pp 569–577 | Cite as

Selective effects of human immunodeficiency virus (HIV) gp120 on invertebrate neurons

  • G. B. Stefano
  • M. Sawada
  • E. M. Smith
  • T. K. Hughes
Article

Summary

  1. 1.

    HIV gp120 selectively reduces the glutamate-induced inward current and the acetylcholine-induced outward current in specific and identifiedAplysia neurons without affecting dopamine (DA)- and serotonin (5-HT)-induced responses.

     
  2. 2.

    gp120 specifically decreases DA levels without significantly altering norepinephrine and 5-HT levels inMytilus pedal ganglia.

     
  3. 3.

    The gp120-associated decrease in DA levels inMytilus is dose dependent and exhibits a threshold level.

     
  4. 4.

    The alteration ofin vitro DA levels is specific for gp120 since anti-gp120 blocks the effect.

     
  5. 5.

    gp120 and its effects appear to be stable due to the duration of treatment and the failure of secondary effects to materialize following antibody treatment.

     

Key words

human immunodeficiency virus (HIV) gp120 invertebrate neurons Mytilus Aplysia 

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Copyright information

© Plenum Publishing Corporation 1993

Authors and Affiliations

  • G. B. Stefano
    • 1
  • M. Sawada
    • 2
  • E. M. Smith
    • 3
  • T. K. Hughes
    • 4
  1. 1.Old Westbury Neuroscience Research InstituteState University of New York at Old WestburyOld WestburyUSA
  2. 2.Department of PhysiologyShimane Medical UniversityIzumoJapan
  3. 3.Department of Psychiatry and Behavioral SciencesUniversity of Texas Medical BranchGalvestonUSA
  4. 4.Department of MicrobiologyUniversity of Texas Medical BranchGalvestonUSA

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